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Emerging role of RNA modification N6-methyladenosine in immune evasion
The innate and adaptive immune cells have complex signaling pathways for sensing and initiating immune responses against disease. These pathways are interrupted at different levels to occur immune evasion, including by N6-methyladenosine (m6A) modification. In this review, we discuss studies reveali...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979796/ https://www.ncbi.nlm.nih.gov/pubmed/33741904 http://dx.doi.org/10.1038/s41419-021-03585-z |
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author | Lou, Xin Wang, Juan-Juan Wei, Ya-Qing Sun, Jin-Jin |
author_facet | Lou, Xin Wang, Juan-Juan Wei, Ya-Qing Sun, Jin-Jin |
author_sort | Lou, Xin |
collection | PubMed |
description | The innate and adaptive immune cells have complex signaling pathways for sensing and initiating immune responses against disease. These pathways are interrupted at different levels to occur immune evasion, including by N6-methyladenosine (m6A) modification. In this review, we discuss studies revealing the immune evasion mechanism by m6A modification, which underlies the retouching of these signaling networks and the rapid tolerance of innate and adaptive immune molecules during disease. We also focus on the functions of m6A in main chemokines regulation, and their roles in promotive and suppressive immune cell recruitment. We then discuss some of the current challenges in the field and describe future directions for the immunological mechanisms of m6A modification. |
format | Online Article Text |
id | pubmed-7979796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79797962021-04-12 Emerging role of RNA modification N6-methyladenosine in immune evasion Lou, Xin Wang, Juan-Juan Wei, Ya-Qing Sun, Jin-Jin Cell Death Dis Review Article The innate and adaptive immune cells have complex signaling pathways for sensing and initiating immune responses against disease. These pathways are interrupted at different levels to occur immune evasion, including by N6-methyladenosine (m6A) modification. In this review, we discuss studies revealing the immune evasion mechanism by m6A modification, which underlies the retouching of these signaling networks and the rapid tolerance of innate and adaptive immune molecules during disease. We also focus on the functions of m6A in main chemokines regulation, and their roles in promotive and suppressive immune cell recruitment. We then discuss some of the current challenges in the field and describe future directions for the immunological mechanisms of m6A modification. Nature Publishing Group UK 2021-03-19 /pmc/articles/PMC7979796/ /pubmed/33741904 http://dx.doi.org/10.1038/s41419-021-03585-z Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Lou, Xin Wang, Juan-Juan Wei, Ya-Qing Sun, Jin-Jin Emerging role of RNA modification N6-methyladenosine in immune evasion |
title | Emerging role of RNA modification N6-methyladenosine in immune evasion |
title_full | Emerging role of RNA modification N6-methyladenosine in immune evasion |
title_fullStr | Emerging role of RNA modification N6-methyladenosine in immune evasion |
title_full_unstemmed | Emerging role of RNA modification N6-methyladenosine in immune evasion |
title_short | Emerging role of RNA modification N6-methyladenosine in immune evasion |
title_sort | emerging role of rna modification n6-methyladenosine in immune evasion |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979796/ https://www.ncbi.nlm.nih.gov/pubmed/33741904 http://dx.doi.org/10.1038/s41419-021-03585-z |
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