Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man(5-9)GlcNAc(2)), expressed on diseased or oxidized RBC surfaces, bind the ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Huan, Antonopoulos, Aristotelis, Henderson, Sadie, Wassall, Heather, Brewin, John, Masson, Alanna, Shepherd, Jenna, Konieczny, Gabriela, Patel, Bhinal, Williams, Maria-Louise, Davie, Adam, Forrester, Megan A., Hall, Lindsay, Minter, Beverley, Tampakis, Dimitris, Moss, Michael, Lennon, Charlotte, Pickford, Wendy, Erwig, Lars, Robertson, Beverley, Dell, Anne, Brown, Gordon D., Wilson, Heather M., Rees, David C., Haslam, Stuart M., Alexandra Rowe, J., Barker, Robert N., Vickers, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979802/
https://www.ncbi.nlm.nih.gov/pubmed/33741926
http://dx.doi.org/10.1038/s41467-021-21814-z

Ejemplares similares

Ejemplares similares