Cargando…

Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches

One of the significant proteins that have attracted research groups due to virtue of being a potent selective anticancer drug target and property of triggering apoptosis upon release in cytoplasm is cytochrome c (cyt c). The mechanical transformations due to the macromolecular crowding in membrane i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parray, Zahoor Ahmad, Ahmad, Faizan, Alajmi, Mohamed F., Hussain, Afzal, Hassan, Md. Imtaiyaz, Islam, Asimul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979836/ https://www.ncbi.nlm.nih.gov/pubmed/33742055 http://dx.doi.org/10.1038/s41598-021-85792-4

Ejemplares similares

Effects of Ethylene Glycol on the Structure and Stability of Myoglobin Using Spectroscopic, Interaction, and In Silico Approaches: Monomer Is Different from Those of Its Polymers
por: Parray, Zahoor Ahmad, et al.
Publicado: (2020)

Measuring Structural Changes in Cytochrome c under Crowded Conditions Using In Vitro and In Silico Approaches
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Rationalizing the Role of Monosodium Glutamate in the Protein Aggregation Through Biophysical Approaches: Potential Impact on Neurodegeneration
por: Ahanger, Ishfaq Ahmad, et al.
Publicado: (2021)

Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Stability of uniformly labeled ((13)C and (15)N) cytochrome c and its L94G mutant
por: Naiyer, Abdullah, et al.
Publicado: (2021)

Heparin Accelerates the Protein Aggregation via the Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to Delineate the Implications on Proteinopathies
por: Ahanger, Ishfaq Ahmad, et al.
Publicado: (2021)

Structural Refolding and Thermal Stability of Myoglobin in the Presence of Mixture of Crowders: Importance of Various Interactions for Protein Stabilization in Crowded Conditions
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies
por: Mohammad, Taj, et al.
Publicado: (2020)

Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders
por: Nasreen, Khalida, et al.
Publicado: (2020)

Trehalose Restrains the Fibril Load towards α-Lactalbumin Aggregation and Halts Fibrillation in a Concentration-Dependent Manner
por: Bashir, Sania, et al.
Publicado: (2021)

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations
por: Amir, Mohd., et al.
Publicado: (2020)

Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents
por: Gupta, Preeti, et al.
Publicado: (2020)

Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches
por: Ali, Nabeel, et al.
Publicado: (2022)

Evaluation of Binding of Rosmarinic Acid with Human Transferrin and Its Impact on the Protein Structure: Targeting Polyphenolic Acid-Induced Protection of Neurodegenerative Disorders
por: Shamsi, Anas, et al.
Publicado: (2020)

Heterogeneity of Equilibrium Molten Globule State of Cytochrome c Induced by Weak Salt Denaturants under Physiological Condition
por: Rahaman, Hamidur, et al.
Publicado: (2015)

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
por: Gupta, Preeti, et al.
Publicado: (2021)

Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1
por: Choudhury, Arunabh, et al.
Publicado: (2021)

Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition
por: Anwar, Saleha, et al.
Publicado: (2020)

Cooperative Unfolding of Residual Structure in Heat Denatured Proteins by Urea and Guanidinium Chloride
por: Singh, Ritu, et al.
Publicado: (2015)

Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus Syndrome
por: Amir, Mohd., et al.
Publicado: (2019)

Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies
por: Khan, Parvez, et al.
Publicado: (2017)

Carbohydrate-Based Macromolecular Crowding-Induced Stabilization of Proteins: Towards Understanding the Significance of the Size of the Crowder
por: Shahid, Sumra, et al.
Publicado: (2019)

Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy
por: Shamsi, Anas, et al.
Publicado: (2020)

Data on the role of accessible surface area on osmolytes-induced protein stabilization
por: Rahman, Safikur, et al.
Publicado: (2016)

Insights into Fluctuations of Structure of Proteins: Significance of Intermediary States in Regulating Biological Functions
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Structure-based functional annotation of hypothetical proteins from Candida dubliniensis: a quest for potential drug targets
por: Kumar, Kundan, et al.
Publicado: (2014)

Purification and characterization of RGA2, a Rho2 GTPase-activating protein from Tinospora cordifolia
por: Amir, Mohd., et al.
Publicado: (2016)

Identification of high-affinity inhibitors of SARS-CoV-2 main protease: Towards the development of effective COVID-19 therapy
por: Mohammad, Taj, et al.
Publicado: (2020)

MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy
por: Shamsi, Anas, et al.
Publicado: (2020)

Testing the Ability of Non-Methylamine Osmolytes Present in Kidney Cells to Counteract the Deleterious Effects of Urea on Structure, Stability and Function of Proteins
por: Khan, Sheeza, et al.
Publicado: (2013)

Biophysical Elucidation of Fibrillation Inhibition by Sugar Osmolytes in α-Lactalbumin: Multispectroscopic and Molecular Docking Approaches
por: Bashir, Sania, et al.
Publicado: (2020)

Sequence Analysis of Hypothetical Proteins from Helicobacter pylori 26695 to Identify Potential Virulence Factors
por: Naqvi, Ahmad Abu Turab, et al.
Publicado: (2016)

Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approach
por: Amir, Mohd., et al.
Publicado: (2019)

Delineating the Aggregation-Prone Hotspot Regions (Peptides) in the Human Cu/Zn Superoxide Dismutase 1
por: Wahiduzzaman,, et al.
Publicado: (2021)

Biophysical Insights into Implications of PEG-400 on the α-Crystallin Structure: Multispectroscopic and Microscopic Approach
por: Shamsi, Anas, et al.
Publicado: (2020)

Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6
por: Yousuf, Mohd, et al.
Publicado: (2020)

Cloning, expression, purification and characterization of human mitochondrial carbonic anhydrase VA
por: Idrees, Danish, et al.
Publicado: (2016)

Ionic Liquid Green Assembly-Mediated Migration of Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug Delivery System
por: Maurya, Neha, et al.
Publicado: (2019)

Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations
por: Kumar, Vijay, et al.
Publicado: (2017)

Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer’s Disease
por: Waseem, Rashid, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fdk5t8j21rfclbbc31pruohqp6