Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our knowledge about innate immune factors of the respiratory tract against SARS-CoV-2 is limited, we generated and screened a peptide/protein library derived from bronchoalveolar lavage for inhibitors of SARS-CoV-2...

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Detalles Bibliográficos
Autores principales: Wettstein, Lukas, Weil, Tatjana, Conzelmann, Carina, Müller, Janis A., Groß, Rüdiger, Hirschenberger, Maximilian, Seidel, Alina, Klute, Susanne, Zech, Fabian, Prelli Bozzo, Caterina, Preising, Nico, Fois, Giorgio, Lochbaum, Robin, Knaff, Philip Maximilian, Mailänder, Volker, Ständker, Ludger, Thal, Dietmar Rudolf, Schumann, Christian, Stenger, Steffen, Kleger, Alexander, Lochnit, Günter, Mayer, Benjamin, Ruiz-Blanco, Yasser B., Hoffmann, Markus, Sparrer, Konstantin M. J., Pöhlmann, Stefan, Sanchez-Garcia, Elsa, Kirchhoff, Frank, Frick, Manfred, Münch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979852/
https://www.ncbi.nlm.nih.gov/pubmed/33741941
http://dx.doi.org/10.1038/s41467-021-21972-0

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