ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE2, is a type I integral membrane protein of 805 amino acids that contains one HEXXH + E zinc-binding consensus sequence. ACE2 has been implicated in the regulation of heart function and also as a functional receptor for the coronav...

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Detalles Bibliográficos
Autores principales: Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2004
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980034/
https://www.ncbi.nlm.nih.gov/pubmed/14754895
http://dx.doi.org/10.1074/jbc.M311191200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980034/
https://www.ncbi.nlm.nih.gov/pubmed/14754895
http://dx.doi.org/10.1074/jbc.M311191200

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