Toward the prevention of coronavirus infection: what role can polymers play?

Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. P...

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Detalles Bibliográficos
Autores principales: Jiang, X., Li, Z., Young, D.J., Liu, M., Wu, C., Wu, Y.-L., Loh, X.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980145/
https://www.ncbi.nlm.nih.gov/pubmed/33778467
http://dx.doi.org/10.1016/j.mtadv.2021.100140
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author Jiang, X.
Li, Z.
Young, D.J.
Liu, M.
Wu, C.
Wu, Y.-L.
Loh, X.J.
author_facet Jiang, X.
Li, Z.
Young, D.J.
Liu, M.
Wu, C.
Wu, Y.-L.
Loh, X.J.
author_sort Jiang, X.
collection PubMed
description Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.
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spelling pubmed-79801452021-03-23 Toward the prevention of coronavirus infection: what role can polymers play? Jiang, X. Li, Z. Young, D.J. Liu, M. Wu, C. Wu, Y.-L. Loh, X.J. Mater Today Adv Article Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics. The Authors. Published by Elsevier Ltd. 2021-06 2021-03-20 /pmc/articles/PMC7980145/ /pubmed/33778467 http://dx.doi.org/10.1016/j.mtadv.2021.100140 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jiang, X.
Li, Z.
Young, D.J.
Liu, M.
Wu, C.
Wu, Y.-L.
Loh, X.J.
Toward the prevention of coronavirus infection: what role can polymers play?
title Toward the prevention of coronavirus infection: what role can polymers play?
title_full Toward the prevention of coronavirus infection: what role can polymers play?
title_fullStr Toward the prevention of coronavirus infection: what role can polymers play?
title_full_unstemmed Toward the prevention of coronavirus infection: what role can polymers play?
title_short Toward the prevention of coronavirus infection: what role can polymers play?
title_sort toward the prevention of coronavirus infection: what role can polymers play?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980145/
https://www.ncbi.nlm.nih.gov/pubmed/33778467
http://dx.doi.org/10.1016/j.mtadv.2021.100140
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