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In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes

The dyads of cardiac myocytes contain ryanodine receptors (RYRs) that generate calcium sparks upon activation. To test how geometric factors of RYR distribution contribute to the formation of calcium sparks, which cannot be addressed experimentally, we performed in silico simulations on a large set...

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Detalles Bibliográficos
Autores principales:	Iaparov, Bogdan I., Zahradnik, Ivan, Moskvin, Alexander S., Zahradníková, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980188/ https://www.ncbi.nlm.nih.gov/pubmed/33735373 http://dx.doi.org/10.1085/jgp.202012685

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