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Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment
Melanoma is the deadliest of all skin cancers due to its high metastatic potential. In recent years, advances in targeted therapy and immunotherapy have contributed to a remarkable progress in the treatment of metastatic disease. However, intrinsic or acquired resistance to such therapies remains a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980219/ https://www.ncbi.nlm.nih.gov/pubmed/33258291 http://dx.doi.org/10.1002/sctm.20-0351 |
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author | Diener, Johanna Sommer, Lukas |
author_facet | Diener, Johanna Sommer, Lukas |
author_sort | Diener, Johanna |
collection | PubMed |
description | Melanoma is the deadliest of all skin cancers due to its high metastatic potential. In recent years, advances in targeted therapy and immunotherapy have contributed to a remarkable progress in the treatment of metastatic disease. However, intrinsic or acquired resistance to such therapies remains a major obstacle in melanoma treatment. Melanoma disease progression, beginning from tumor initiation and growth to acquisition of invasive phenotypes and metastatic spread and acquisition of treatment resistance, has been associated with cellular dedifferentiation and the hijacking of gene regulatory networks reminiscent of the neural crest (NC)—the developmental structure which gives rise to melanocytes and hence melanoma. This review summarizes the experimental evidence for the involvement of NC stem cell (NCSC)‐like cell states during melanoma progression and addresses novel approaches to combat the emergence of stemness characteristics that have shown to be linked with aggressive disease outcome and drug resistance. |
format | Online Article Text |
id | pubmed-7980219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79802192021-03-23 Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment Diener, Johanna Sommer, Lukas Stem Cells Transl Med Concise Review Melanoma is the deadliest of all skin cancers due to its high metastatic potential. In recent years, advances in targeted therapy and immunotherapy have contributed to a remarkable progress in the treatment of metastatic disease. However, intrinsic or acquired resistance to such therapies remains a major obstacle in melanoma treatment. Melanoma disease progression, beginning from tumor initiation and growth to acquisition of invasive phenotypes and metastatic spread and acquisition of treatment resistance, has been associated with cellular dedifferentiation and the hijacking of gene regulatory networks reminiscent of the neural crest (NC)—the developmental structure which gives rise to melanocytes and hence melanoma. This review summarizes the experimental evidence for the involvement of NC stem cell (NCSC)‐like cell states during melanoma progression and addresses novel approaches to combat the emergence of stemness characteristics that have shown to be linked with aggressive disease outcome and drug resistance. John Wiley & Sons, Inc. 2020-12-01 /pmc/articles/PMC7980219/ /pubmed/33258291 http://dx.doi.org/10.1002/sctm.20-0351 Text en © 2020 The Authors. stem cells translational medicine published by Wiley Periodicals LLC on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Concise Review Diener, Johanna Sommer, Lukas Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
title | Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
title_full | Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
title_fullStr | Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
title_full_unstemmed | Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
title_short | Reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
title_sort | reemergence of neural crest stem cell‐like states in melanoma during disease progression and treatment |
topic | Concise Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980219/ https://www.ncbi.nlm.nih.gov/pubmed/33258291 http://dx.doi.org/10.1002/sctm.20-0351 |
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