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The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whether transmembrane protein-specific QC hubs exist. Here we...

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Detalles Bibliográficos
Autores principales:	Heider, Michael, Eichner, Ruth, Stroh, Jacob, Morath, Volker, Kuisl, Anna, Zecha, Jana, Lawatscheck, Jannis, Baek, Kheewoong, Garz, Anne-Kathrin, Rudelius, Martina, Deuschle, Friedrich-Christian, Keller, Ulrich, Lemeer, Simone, Verbeek, Mareike, Götze, Katharina S., Skerra, Arne, Weber, Wolfgang A., Buchner, Johannes, Schulman, Brenda A., Kuster, Bernhard, Fernández-Sáiz, Vanesa, Bassermann, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980223/ https://www.ncbi.nlm.nih.gov/pubmed/33571422 http://dx.doi.org/10.1016/j.molcel.2020.12.046

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