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A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding

Plant viruses employ diverse virulence strategies to achieve successful infection, but there are few known general strategies of viral pathogenicity and transmission used by widely different plant viruses. Here, we report a class of independently evolved virulence factors in different plant RNA viru...

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Autores principales: Li, Lulu, Zhang, Hehong, Chen, Changhai, Huang, Haijian, Tan, Xiaoxiang, Wei, Zhongyan, Li, Junmin, Yan, Fei, Zhang, Chuanxi, Chen, Jianping, Sun, Zongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980396/
https://www.ncbi.nlm.nih.gov/pubmed/33836579
http://dx.doi.org/10.1073/pnas.2016673118
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author Li, Lulu
Zhang, Hehong
Chen, Changhai
Huang, Haijian
Tan, Xiaoxiang
Wei, Zhongyan
Li, Junmin
Yan, Fei
Zhang, Chuanxi
Chen, Jianping
Sun, Zongtao
author_facet Li, Lulu
Zhang, Hehong
Chen, Changhai
Huang, Haijian
Tan, Xiaoxiang
Wei, Zhongyan
Li, Junmin
Yan, Fei
Zhang, Chuanxi
Chen, Jianping
Sun, Zongtao
author_sort Li, Lulu
collection PubMed
description Plant viruses employ diverse virulence strategies to achieve successful infection, but there are few known general strategies of viral pathogenicity and transmission used by widely different plant viruses. Here, we report a class of independently evolved virulence factors in different plant RNA viruses which possess active transcriptional repressor activity. Rice viruses in the genera Fijivirus, Tenuivirus, and Cytorhabdovirus all have transcriptional repressors that interact in plants with the key components of jasmonic acid (JA) signaling, namely mediator subunit OsMED25, OsJAZ proteins, and OsMYC transcription factors. These transcriptional repressors can directly disassociate the OsMED25-OsMYC complex, inhibit the transcriptional activation of OsMYC, and then combine with OsJAZ proteins to cooperatively attenuate the JA pathway in a way that benefits viral infection. At the same time, these transcriptional repressors efficiently enhanced feeding by the virus insect vectors by repressing JA signaling. Our findings reveal a common strategy in unrelated plant viruses in which viral transcriptional repressors hijack and repress the JA pathway in favor of both viral pathogenicity and vector transmission.
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spelling pubmed-79803962021-03-26 A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding Li, Lulu Zhang, Hehong Chen, Changhai Huang, Haijian Tan, Xiaoxiang Wei, Zhongyan Li, Junmin Yan, Fei Zhang, Chuanxi Chen, Jianping Sun, Zongtao Proc Natl Acad Sci U S A Biological Sciences Plant viruses employ diverse virulence strategies to achieve successful infection, but there are few known general strategies of viral pathogenicity and transmission used by widely different plant viruses. Here, we report a class of independently evolved virulence factors in different plant RNA viruses which possess active transcriptional repressor activity. Rice viruses in the genera Fijivirus, Tenuivirus, and Cytorhabdovirus all have transcriptional repressors that interact in plants with the key components of jasmonic acid (JA) signaling, namely mediator subunit OsMED25, OsJAZ proteins, and OsMYC transcription factors. These transcriptional repressors can directly disassociate the OsMED25-OsMYC complex, inhibit the transcriptional activation of OsMYC, and then combine with OsJAZ proteins to cooperatively attenuate the JA pathway in a way that benefits viral infection. At the same time, these transcriptional repressors efficiently enhanced feeding by the virus insect vectors by repressing JA signaling. Our findings reveal a common strategy in unrelated plant viruses in which viral transcriptional repressors hijack and repress the JA pathway in favor of both viral pathogenicity and vector transmission. National Academy of Sciences 2021-03-16 2021-03-08 /pmc/articles/PMC7980396/ /pubmed/33836579 http://dx.doi.org/10.1073/pnas.2016673118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Li, Lulu
Zhang, Hehong
Chen, Changhai
Huang, Haijian
Tan, Xiaoxiang
Wei, Zhongyan
Li, Junmin
Yan, Fei
Zhang, Chuanxi
Chen, Jianping
Sun, Zongtao
A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
title A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
title_full A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
title_fullStr A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
title_full_unstemmed A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
title_short A class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
title_sort class of independently evolved transcriptional repressors in plant rna viruses facilitates viral infection and vector feeding
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980396/
https://www.ncbi.nlm.nih.gov/pubmed/33836579
http://dx.doi.org/10.1073/pnas.2016673118
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