Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways

New therapeutic approaches to resolve persistent pain are highly needed. We tested the hypothesis that manipulation of cytokine receptors on sensory neurons by clustering regulatory cytokine receptor pairs with a fusion protein of interleukin (IL)-4 and IL-10 (IL4–10 FP) would redirect signaling pat...

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Detalles Bibliográficos
Autores principales: Prado, Judith, Westerink, Remco H. S., Popov-Celeketic, Jelena, Steen-Louws, Cristine, Pandit, Aridaman, Versteeg, Sabine, van de Worp, Wouter, Kanters, Deon H. A. J., Reedquist, Kris A., Koenderman, Leo, Hack, C. Erik, Eijkelkamp, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980471/
https://www.ncbi.nlm.nih.gov/pubmed/33836560
http://dx.doi.org/10.1073/pnas.2009647118

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