Cargando…

Synthesis, Molecular Docking, In Silico ADME Predictions, and Toxicity Studies of N-Substituted-5-(4-Chloroquinolin-2-yl)-1,3,4-Thiadiazol-2-Amine Derivatives as COVID-19 Inhibitors

The present study aimed to synthesis N-substituted-5-(4-chloroquinolin-2-yl)-1,3,4-thiadiazol-2-amine derivatives. Molecular docking study of the synthesized compounds was carried out. COVID-19 docked with the synthesized compounds and the results indicated that the binding energies of docking 6LU7...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanaa S. Mohamed, El-Serwy, Walaa S., El-Serwy, Weam S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pleiades Publishing 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980798/ https://www.ncbi.nlm.nih.gov/pubmed/33776395 http://dx.doi.org/10.1134/S1068162021010155

Ejemplares similares

Synthesis of (2-chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides
por: Aksenov, A. N., et al.
Publicado: (2021)

5-(4-Pyridyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
por: Guan, Jian-Ning, et al.
Publicado: (2009)

5-(4-Phenoxyphenyl)-1,3,4-thiadiazol-2-amine
por: Wan, Rong, et al.
Publicado: (2009)

5-(4-Pentylphenyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(Adamantan-1-yl)-N-methyl-1,3,4-thiadiazol-2-amine
por: Al-Tamimi, Abdul-Malek S., et al.
Publicado: (2013)

Novel asymmetrical azines appending 1,3,4-thiadiazole sulfonamide: synthesis, molecular structure analyses, in silico ADME, and cytotoxic effect
por: Bondock, Samir, et al.
Publicado: (2023)

5-(3-Pyridyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives
por: Kokovina, Tatiana S., et al.
Publicado: (2021)

Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles
por: Ergena, Asrat, et al.
Publicado: (2022)

5-(2-Bromophenyl)-1,3,4-thiadiazol-2-amine
por: Yin, Li-He, et al.
Publicado: (2008)

5-(2-Methylphenyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides
por: Alminderej, Fahad M., et al.
Publicado: (2019)

Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
por: El-serwy, Walaa S., et al.
Publicado: (2016)

5-(4-Bromo-2-nitrophenyl)-1,3,4-thiadiazol-2-amine
por: Zhang, Jian-qiang, et al.
Publicado: (2011)

5-(2,4-Dichlorophenoxymethyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(2-Fluoro-4-nitrophenyl)-1,3,4-thiadiazole-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(3-Fluorophenyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(3-Nitrobenzyl)-1,3,4-thiadiazol-2-amine
por: Carvalho, Samir A., et al.
Publicado: (2009)

5-({3-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]benzyl}sulfanyl)-1,3,4-thiadiazol-2-amine
por: Kang, Sung Kwon, et al.
Publicado: (2012)

5-(Thiophen-2-ylmethyl)-1,3,4-thiadiazol-2-amine
por: Köysal, Yavuz, et al.
Publicado: (2012)

5-(2,6-Difluorophenyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

(E)-5-Phenyl-N-(2-thienylmethylene)-1,3,4-thiadiazole-2-amine
por: Demirtaş, Güneş, et al.
Publicado: (2009)

2-(4-Fluorobenzylidene)-N-(4-methoxybenzylidene)-1,3,4-thiadiazol-2-amine
por: He, Qiu, et al.
Publicado: (2010)

Quantitative assessment of the nature of noncovalent interactions in N-substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis
por: El-Emam, Ali A., et al.
Publicado: (2020)

5,5′-[Methylenebis(sulfanediyl)]bis(1,3,4-thiadiazol-2-amine)
por: Meng, Fankun
Publicado: (2008)

N,N-Bis(2,6-difluorobenzyl)-1,3,4-thiadiazol-2-amine
por: Fun, Hoong-Kun, et al.
Publicado: (2009)

5-(2,3,4,5,6-Pentafluorophenyl)-1,3,4-thiadiazol-2-amine
por: Wang, Peng, et al.
Publicado: (2010)

Synthesis of new, highly luminescent bis(2,2’-bithiophen-5-yl) substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole
por: Kostyuchenko, Anastasia S, et al.
Publicado: (2014)

5-({[(E)-Benzylideneamino]oxy}methyl)-1,3,4-thiadiazol-2-amine
por: Yin, Weiyan, et al.
Publicado: (2012)

Dichloridobis(5-heptyl-1,3,4-thiadiazol-2-amine-κN (3))zinc(II)
por: Wang, Peng, et al.
Publicado: (2009)

(E)-N-(4-Chlorobenzylidene)-5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine
por: Yu, Peng, et al.
Publicado: (2011)

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
por: Rezki, Nadjet, et al.
Publicado: (2015)

4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
por: Sharma, Deepika, et al.
Publicado: (2019)

Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides
por: Flefel, Eman M., et al.
Publicado: (2017)

2-(Nitroaryl)-5-Substituted-1,3,4-Thiadiazole Derivatives with Antiprotozoal Activities: In Vitro and In Vivo Study
por: Mousavi, Alireza, et al.
Publicado: (2022)

5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
por: Gomha, Sobhi M, et al.
Publicado: (2018)

Bis(1,3,4-thiadiazol-2-yl) disulfide
por: Hu, Pu-Zhou, et al.
Publicado: (2009)

In silico ADME predictions and in vitro antibacterial evaluation of 2-hydroxy benzothiazole-based 1,3,4-oxadiazole derivatives
por: ALGHAMDI, Afnan Ahmed, et al.
Publicado: (2020)

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles
por: Janowska, Sara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m1u0qh6ms8kfrlhdvt73fndfqd