Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases

This review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of infectious diseases caused by Haemophilus influenzae type b bacteria based on the linear capsular polysaccharide poly-3-β-D-ribosyl-(1→1)-D-ribitol-5-phosphate (PRP)...

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Detalles Bibliográficos
Autores principales: Khatuntseva, E. A., Nifantiev, N. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980804/
https://www.ncbi.nlm.nih.gov/pubmed/33776394
http://dx.doi.org/10.1134/S1068162021010106
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author Khatuntseva, E. A.
Nifantiev, N. E.
author_facet Khatuntseva, E. A.
Nifantiev, N. E.
author_sort Khatuntseva, E. A.
collection PubMed
description This review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of infectious diseases caused by Haemophilus influenzae type b bacteria based on the linear capsular polysaccharide poly-3-β-D-ribosyl-(1→1)-D-ribitol-5-phosphate (PRP) or related synthetic oligosaccharide ligands. The methods for preparation of related oligosaccharide derivatives and results of the studies evaluating effect of their length on immunogenic properties of the conjugates with protein carriers are overviewed.
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spelling pubmed-79808042021-03-23 Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases Khatuntseva, E. A. Nifantiev, N. E. Russ J Bioorg Chem Review Article This review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of infectious diseases caused by Haemophilus influenzae type b bacteria based on the linear capsular polysaccharide poly-3-β-D-ribosyl-(1→1)-D-ribitol-5-phosphate (PRP) or related synthetic oligosaccharide ligands. The methods for preparation of related oligosaccharide derivatives and results of the studies evaluating effect of their length on immunogenic properties of the conjugates with protein carriers are overviewed. Pleiades Publishing 2021-03-20 2021 /pmc/articles/PMC7980804/ /pubmed/33776394 http://dx.doi.org/10.1134/S1068162021010106 Text en © Pleiades Publishing, Ltd. 2021, ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2021, Vol. 47, No. 1, pp. 26–52. © Pleiades Publishing, Ltd., 2021.Russian Text © The Author(s), 2021, published in Bioorganicheskaya Khimiya, 2021, Vol. 47, No. 1, pp. 29–56. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Khatuntseva, E. A.
Nifantiev, N. E.
Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
title Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
title_full Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
title_fullStr Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
title_full_unstemmed Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
title_short Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
title_sort glycoconjugate vaccines for prevention of haemophilus influenzae type b diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980804/
https://www.ncbi.nlm.nih.gov/pubmed/33776394
http://dx.doi.org/10.1134/S1068162021010106
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