miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ

In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p cou...

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Detalles Bibliográficos
Autores principales: Wang, Xuehui, Yao, Zhilu, Fang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981180/
https://www.ncbi.nlm.nih.gov/pubmed/33777130
http://dx.doi.org/10.1155/2021/6661828
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author Wang, Xuehui
Yao, Zhilu
Fang, Lin
author_facet Wang, Xuehui
Yao, Zhilu
Fang, Lin
author_sort Wang, Xuehui
collection PubMed
description In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target.
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spelling pubmed-79811802021-03-26 miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ Wang, Xuehui Yao, Zhilu Fang, Lin PPAR Res Research Article In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target. Hindawi 2021-03-12 /pmc/articles/PMC7981180/ /pubmed/33777130 http://dx.doi.org/10.1155/2021/6661828 Text en Copyright © 2021 Xuehui Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Xuehui
Yao, Zhilu
Fang, Lin
miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
title miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
title_full miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
title_fullStr miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
title_full_unstemmed miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
title_short miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
title_sort mir-22-3p/pgc1β suppresses breast cancer cell tumorigenesis via pparγ
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981180/
https://www.ncbi.nlm.nih.gov/pubmed/33777130
http://dx.doi.org/10.1155/2021/6661828
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