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Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation
BACKGROUND: Bone marrow transplantation is now an established treatment for some hematopoietic disorders and hematopoietic malignancies, and secondary solid tumors that develop after bone marrow transplantation have begun to attract attention. CASE PRESENTATION: Herein, we report 3 cases of esophage...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981339/ https://www.ncbi.nlm.nih.gov/pubmed/33744998 http://dx.doi.org/10.1186/s40792-021-01157-z |
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author | Ninomiya, Yamato Ozawa, Soji Koyanagi, Kazuo Yamamoto, Miho Higuchi, Tadashi Yatabe, Kentaro Tajima, Kohei |
author_facet | Ninomiya, Yamato Ozawa, Soji Koyanagi, Kazuo Yamamoto, Miho Higuchi, Tadashi Yatabe, Kentaro Tajima, Kohei |
author_sort | Ninomiya, Yamato |
collection | PubMed |
description | BACKGROUND: Bone marrow transplantation is now an established treatment for some hematopoietic disorders and hematopoietic malignancies, and secondary solid tumors that develop after bone marrow transplantation have begun to attract attention. CASE PRESENTATION: Herein, we report 3 cases of esophageal carcinoma that developed after bone marrow transplantation. Case 1: 40-year-old female received cyclophosphamide and total body irradiation at 12 Gy for acute myeloid leukemia, followed by related bone marrow transplantation. She developed chronic graft-versus-host disease manifesting as pulmonary complications and was administered cyclosporine. Nine years after the transplantation, she was diagnosed as having esophageal carcinoma Stage II and underwent radical surgery. She died of the primary disease 17 months after the surgery. Case 2: A 45-year-old male patient received cyclophosphamide, VP-16 and total body irradiation at 13.2 Gy for acute lymphocytic leukemia, followed by related bone marrow transplantation. He developed chronic graft-versus-host disease manifesting as liver dysfunction. Fifteen years after the transplantation, he was diagnosed as having esophageal carcinoma Stage II and underwent radical surgery. Seven months after the surgery, he died of the primary disease. Case 3: A 30-year-old female patient received cyclophosphamide and total body irradiation at 3 Gy for Fanconi anemia, followed by unrelated bone marrow transplantation. She developed chronic graft-versus-host disease manifesting as a rash and was administered tacrolimus and methotrexate. Fifteen years after the transplantation, she was diagnosed as having esophageal carcinoma Stage III and underwent radical surgery. She died of sepsis 7 months after the surgery. CONCLUSION: The esophageal carcinomas developing after bone marrow transplantation had the characteristics of secondary solid tumors in all 3 patients, such as early onset, after total body irradiation, association with chronic graft-versus-host disease, and history of use of immunosuppressive drugs. Patients undergoing bone marrow transplantation require long-term follow-up after the transplantation, considering the possible development of secondary solid tumors, and in regard to secondary solid tumors developing in the gastrointestinal tract, it must be borne in mind that the risk of esophageal carcinoma is particularly high. |
format | Online Article Text |
id | pubmed-7981339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-79813392021-04-12 Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation Ninomiya, Yamato Ozawa, Soji Koyanagi, Kazuo Yamamoto, Miho Higuchi, Tadashi Yatabe, Kentaro Tajima, Kohei Surg Case Rep Case Report BACKGROUND: Bone marrow transplantation is now an established treatment for some hematopoietic disorders and hematopoietic malignancies, and secondary solid tumors that develop after bone marrow transplantation have begun to attract attention. CASE PRESENTATION: Herein, we report 3 cases of esophageal carcinoma that developed after bone marrow transplantation. Case 1: 40-year-old female received cyclophosphamide and total body irradiation at 12 Gy for acute myeloid leukemia, followed by related bone marrow transplantation. She developed chronic graft-versus-host disease manifesting as pulmonary complications and was administered cyclosporine. Nine years after the transplantation, she was diagnosed as having esophageal carcinoma Stage II and underwent radical surgery. She died of the primary disease 17 months after the surgery. Case 2: A 45-year-old male patient received cyclophosphamide, VP-16 and total body irradiation at 13.2 Gy for acute lymphocytic leukemia, followed by related bone marrow transplantation. He developed chronic graft-versus-host disease manifesting as liver dysfunction. Fifteen years after the transplantation, he was diagnosed as having esophageal carcinoma Stage II and underwent radical surgery. Seven months after the surgery, he died of the primary disease. Case 3: A 30-year-old female patient received cyclophosphamide and total body irradiation at 3 Gy for Fanconi anemia, followed by unrelated bone marrow transplantation. She developed chronic graft-versus-host disease manifesting as a rash and was administered tacrolimus and methotrexate. Fifteen years after the transplantation, she was diagnosed as having esophageal carcinoma Stage III and underwent radical surgery. She died of sepsis 7 months after the surgery. CONCLUSION: The esophageal carcinomas developing after bone marrow transplantation had the characteristics of secondary solid tumors in all 3 patients, such as early onset, after total body irradiation, association with chronic graft-versus-host disease, and history of use of immunosuppressive drugs. Patients undergoing bone marrow transplantation require long-term follow-up after the transplantation, considering the possible development of secondary solid tumors, and in regard to secondary solid tumors developing in the gastrointestinal tract, it must be borne in mind that the risk of esophageal carcinoma is particularly high. Springer Berlin Heidelberg 2021-03-20 /pmc/articles/PMC7981339/ /pubmed/33744998 http://dx.doi.org/10.1186/s40792-021-01157-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Case Report Ninomiya, Yamato Ozawa, Soji Koyanagi, Kazuo Yamamoto, Miho Higuchi, Tadashi Yatabe, Kentaro Tajima, Kohei Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
title | Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
title_full | Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
title_fullStr | Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
title_full_unstemmed | Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
title_short | Three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
title_sort | three resected cases of esophageal carcinoma considered as being secondary solid tumors after bone marrow transplantation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981339/ https://www.ncbi.nlm.nih.gov/pubmed/33744998 http://dx.doi.org/10.1186/s40792-021-01157-z |
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