Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Chen, Peng, Yue-Ling, He, Juan, Li, Zheng-Hui, Liu, Ji-Kai, Feng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981340/
https://www.ncbi.nlm.nih.gov/pubmed/33449279
http://dx.doi.org/10.1007/s13659-021-00297-x
_version_ 1783667533856899072
author Shi, Chen
Peng, Yue-Ling
He, Juan
Li, Zheng-Hui
Liu, Ji-Kai
Feng, Tao
author_facet Shi, Chen
Peng, Yue-Ling
He, Juan
Li, Zheng-Hui
Liu, Ji-Kai
Feng, Tao
author_sort Shi, Chen
collection PubMed
description Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC(50) values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly. [Image: see text]
format Online
Article
Text
id pubmed-7981340
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Singapore
record_format MEDLINE/PubMed
spelling pubmed-79813402021-04-12 Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum Shi, Chen Peng, Yue-Ling He, Juan Li, Zheng-Hui Liu, Ji-Kai Feng, Tao Nat Prod Bioprospect Original Article Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC(50) values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly. [Image: see text] Springer Singapore 2021-01-15 /pmc/articles/PMC7981340/ /pubmed/33449279 http://dx.doi.org/10.1007/s13659-021-00297-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Shi, Chen
Peng, Yue-Ling
He, Juan
Li, Zheng-Hui
Liu, Ji-Kai
Feng, Tao
Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
title Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
title_full Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
title_fullStr Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
title_full_unstemmed Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
title_short Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum
title_sort structures, chemical conversions, and cytotoxicity of tricholopardins c and d, two tricholoma triterpenoids from the wild mushroom tricholoma pardinum
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981340/
https://www.ncbi.nlm.nih.gov/pubmed/33449279
http://dx.doi.org/10.1007/s13659-021-00297-x
work_keys_str_mv AT shichen structureschemicalconversionsandcytotoxicityoftricholopardinscanddtwotricholomatriterpenoidsfromthewildmushroomtricholomapardinum
AT pengyueling structureschemicalconversionsandcytotoxicityoftricholopardinscanddtwotricholomatriterpenoidsfromthewildmushroomtricholomapardinum
AT hejuan structureschemicalconversionsandcytotoxicityoftricholopardinscanddtwotricholomatriterpenoidsfromthewildmushroomtricholomapardinum
AT lizhenghui structureschemicalconversionsandcytotoxicityoftricholopardinscanddtwotricholomatriterpenoidsfromthewildmushroomtricholomapardinum
AT liujikai structureschemicalconversionsandcytotoxicityoftricholopardinscanddtwotricholomatriterpenoidsfromthewildmushroomtricholomapardinum
AT fengtao structureschemicalconversionsandcytotoxicityoftricholopardinscanddtwotricholomatriterpenoidsfromthewildmushroomtricholomapardinum

Ejemplares similares