Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis

ABSTRACT: Four new monoterpenoid indole alkaloids, bousmekines A-D (1–4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a comb...

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Autores principales: Huo, Zong-Qing, Zhao, Qian, Zhu, Wen-Tao, Hao, Xiao-Jiang, Zhang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981358/
https://www.ncbi.nlm.nih.gov/pubmed/33140311
http://dx.doi.org/10.1007/s13659-020-00278-6
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author Huo, Zong-Qing
Zhao, Qian
Zhu, Wen-Tao
Hao, Xiao-Jiang
Zhang, Yu
author_facet Huo, Zong-Qing
Zhao, Qian
Zhu, Wen-Tao
Hao, Xiao-Jiang
Zhang, Yu
author_sort Huo, Zong-Qing
collection PubMed
description ABSTRACT: Four new monoterpenoid indole alkaloids, bousmekines A-D (1–4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC(50) values of 0.8–7.4 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-020-00278-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-79813582021-04-12 Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis Huo, Zong-Qing Zhao, Qian Zhu, Wen-Tao Hao, Xiao-Jiang Zhang, Yu Nat Prod Bioprospect Original Article ABSTRACT: Four new monoterpenoid indole alkaloids, bousmekines A-D (1–4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC(50) values of 0.8–7.4 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-020-00278-6) contains supplementary material, which is available to authorized users. Springer Singapore 2020-11-03 /pmc/articles/PMC7981358/ /pubmed/33140311 http://dx.doi.org/10.1007/s13659-020-00278-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Huo, Zong-Qing
Zhao, Qian
Zhu, Wen-Tao
Hao, Xiao-Jiang
Zhang, Yu
Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis
title Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis
title_full Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis
title_fullStr Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis
title_full_unstemmed Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis
title_short Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis
title_sort bousmekines a-e, new alkaloids from two bousigonia species: b.angustifolia and b. mekongensis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981358/
https://www.ncbi.nlm.nih.gov/pubmed/33140311
http://dx.doi.org/10.1007/s13659-020-00278-6
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