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Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment
Short-term symptomatic treatment and dose-dependent side effects of pharmacological treatment for neurodegenerative diseases have forced the medical community to seek an effective treatment for this serious global health threat. Therapeutic potential of stem cell for treatment of neurodegenerative d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981389/ https://www.ncbi.nlm.nih.gov/pubmed/33745116 http://dx.doi.org/10.1007/s12035-021-02324-x |
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author | Fayazi, Nashmin Sheykhhasan, Mohsen Soleimani Asl, Sara Najafi, Rezvan |
author_facet | Fayazi, Nashmin Sheykhhasan, Mohsen Soleimani Asl, Sara Najafi, Rezvan |
author_sort | Fayazi, Nashmin |
collection | PubMed |
description | Short-term symptomatic treatment and dose-dependent side effects of pharmacological treatment for neurodegenerative diseases have forced the medical community to seek an effective treatment for this serious global health threat. Therapeutic potential of stem cell for treatment of neurodegenerative disorders was identified in 1980 when fetal nerve tissue was used to treat Parkinson’s disease (PD). Then, extensive studies have been conducted to develop this treatment strategy for neurological disease therapy. Today, stem cells and their secretion are well-known as a therapeutic environment for the treatment of neurodegenerative diseases. This new paradigm has demonstrated special characteristics related to this treatment, including neuroprotective and neurodegeneration, remyelination, reduction of neural inflammation, and recovery of function after induced injury. However, the exact mechanism of stem cells in repairing nerve damage is not yet clear; exosomes derived from them, an important part of their secretion, are introduced as responsible for an important part of such effects. Numerous studies over the past few decades have evaluated the therapeutic potential of exosomes in the treatment of various neurological diseases. In this review, after recalling the features and therapeutic history, we will discuss the latest stem cell-derived exosome-based therapies for these diseases. |
format | Online Article Text |
id | pubmed-7981389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-79813892021-03-23 Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment Fayazi, Nashmin Sheykhhasan, Mohsen Soleimani Asl, Sara Najafi, Rezvan Mol Neurobiol Article Short-term symptomatic treatment and dose-dependent side effects of pharmacological treatment for neurodegenerative diseases have forced the medical community to seek an effective treatment for this serious global health threat. Therapeutic potential of stem cell for treatment of neurodegenerative disorders was identified in 1980 when fetal nerve tissue was used to treat Parkinson’s disease (PD). Then, extensive studies have been conducted to develop this treatment strategy for neurological disease therapy. Today, stem cells and their secretion are well-known as a therapeutic environment for the treatment of neurodegenerative diseases. This new paradigm has demonstrated special characteristics related to this treatment, including neuroprotective and neurodegeneration, remyelination, reduction of neural inflammation, and recovery of function after induced injury. However, the exact mechanism of stem cells in repairing nerve damage is not yet clear; exosomes derived from them, an important part of their secretion, are introduced as responsible for an important part of such effects. Numerous studies over the past few decades have evaluated the therapeutic potential of exosomes in the treatment of various neurological diseases. In this review, after recalling the features and therapeutic history, we will discuss the latest stem cell-derived exosome-based therapies for these diseases. Springer US 2021-03-21 2021 /pmc/articles/PMC7981389/ /pubmed/33745116 http://dx.doi.org/10.1007/s12035-021-02324-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Fayazi, Nashmin Sheykhhasan, Mohsen Soleimani Asl, Sara Najafi, Rezvan Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment |
title | Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment |
title_full | Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment |
title_fullStr | Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment |
title_full_unstemmed | Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment |
title_short | Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment |
title_sort | stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981389/ https://www.ncbi.nlm.nih.gov/pubmed/33745116 http://dx.doi.org/10.1007/s12035-021-02324-x |
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