Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report

Drug‐drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S‐1 (tegafur/gimeracil/oteracil) and rad...

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Autores principales: Shiraiwa, Ken, Ono, Hiroyuki, Tanaka, Ryota, Fujinaga, Atsuro, Hiratsuka, Takahiro, Tatsuta, Ryosuke, Inomata, Masafumi, Itoh, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981613/
https://www.ncbi.nlm.nih.gov/pubmed/33768879
http://dx.doi.org/10.1002/ccr3.3813
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author Shiraiwa, Ken
Ono, Hiroyuki
Tanaka, Ryota
Fujinaga, Atsuro
Hiratsuka, Takahiro
Tatsuta, Ryosuke
Inomata, Masafumi
Itoh, Hiroki
author_facet Shiraiwa, Ken
Ono, Hiroyuki
Tanaka, Ryota
Fujinaga, Atsuro
Hiratsuka, Takahiro
Tatsuta, Ryosuke
Inomata, Masafumi
Itoh, Hiroki
author_sort Shiraiwa, Ken
collection PubMed
description Drug‐drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S‐1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.
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spelling pubmed-79816132021-03-24 Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report Shiraiwa, Ken Ono, Hiroyuki Tanaka, Ryota Fujinaga, Atsuro Hiratsuka, Takahiro Tatsuta, Ryosuke Inomata, Masafumi Itoh, Hiroki Clin Case Rep Case Reports Drug‐drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S‐1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer. John Wiley and Sons Inc. 2021-02-04 /pmc/articles/PMC7981613/ /pubmed/33768879 http://dx.doi.org/10.1002/ccr3.3813 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Shiraiwa, Ken
Ono, Hiroyuki
Tanaka, Ryota
Fujinaga, Atsuro
Hiratsuka, Takahiro
Tatsuta, Ryosuke
Inomata, Masafumi
Itoh, Hiroki
Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
title Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
title_full Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
title_fullStr Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
title_full_unstemmed Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
title_short Effect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
title_sort effect of s‐1 on blood levels of phenobarbital and phenytoin: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981613/
https://www.ncbi.nlm.nih.gov/pubmed/33768879
http://dx.doi.org/10.1002/ccr3.3813
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