Significant elevation of free itraconazole concentration at onset of adverse effects: A case report

Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects...

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Autores principales: Tanaka, Ryota, Suzuki, Yosuke, Matsumoto, Hiroyuki, Yamasue, Mari, Umeki, Kenji, Hashinaga, Kazuhiko, Tatsuta, Ryosuke, Hiramatsu, Kazufumi, Kamei, Katsuhiko, Kadota, Jun‐ichi, Itoh, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981736/
https://www.ncbi.nlm.nih.gov/pubmed/33768808
http://dx.doi.org/10.1002/ccr3.3726
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author Tanaka, Ryota
Suzuki, Yosuke
Matsumoto, Hiroyuki
Yamasue, Mari
Umeki, Kenji
Hashinaga, Kazuhiko
Tatsuta, Ryosuke
Hiramatsu, Kazufumi
Kamei, Katsuhiko
Kadota, Jun‐ichi
Itoh, Hiroki
author_facet Tanaka, Ryota
Suzuki, Yosuke
Matsumoto, Hiroyuki
Yamasue, Mari
Umeki, Kenji
Hashinaga, Kazuhiko
Tatsuta, Ryosuke
Hiramatsu, Kazufumi
Kamei, Katsuhiko
Kadota, Jun‐ichi
Itoh, Hiroki
author_sort Tanaka, Ryota
collection PubMed
description Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.
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spelling pubmed-79817362021-03-24 Significant elevation of free itraconazole concentration at onset of adverse effects: A case report Tanaka, Ryota Suzuki, Yosuke Matsumoto, Hiroyuki Yamasue, Mari Umeki, Kenji Hashinaga, Kazuhiko Tatsuta, Ryosuke Hiramatsu, Kazufumi Kamei, Katsuhiko Kadota, Jun‐ichi Itoh, Hiroki Clin Case Rep Case Reports Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects. John Wiley and Sons Inc. 2021-01-14 /pmc/articles/PMC7981736/ /pubmed/33768808 http://dx.doi.org/10.1002/ccr3.3726 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Tanaka, Ryota
Suzuki, Yosuke
Matsumoto, Hiroyuki
Yamasue, Mari
Umeki, Kenji
Hashinaga, Kazuhiko
Tatsuta, Ryosuke
Hiramatsu, Kazufumi
Kamei, Katsuhiko
Kadota, Jun‐ichi
Itoh, Hiroki
Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
title Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
title_full Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
title_fullStr Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
title_full_unstemmed Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
title_short Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
title_sort significant elevation of free itraconazole concentration at onset of adverse effects: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981736/
https://www.ncbi.nlm.nih.gov/pubmed/33768808
http://dx.doi.org/10.1002/ccr3.3726
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