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Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study

BACKGROUND: Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whether there was a correlation between the serum creatine phosphokinase (CPK) level,...

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Autores principales: Mülkoğlu, Cevriye, Karaosmanoğlu, Nermin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981891/
https://www.ncbi.nlm.nih.gov/pubmed/33743831
http://dx.doi.org/10.1186/s40360-021-00483-0
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author Mülkoğlu, Cevriye
Karaosmanoğlu, Nermin
author_facet Mülkoğlu, Cevriye
Karaosmanoğlu, Nermin
author_sort Mülkoğlu, Cevriye
collection PubMed
description BACKGROUND: Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whether there was a correlation between the serum creatine phosphokinase (CPK) level, a specific marker of muscle breakdown, and muscle strength. METHODS: This study included 30 patients who presented to our hospital and were started on oral isotretinoin treatment for acne vulgaris and 30 patients in the control group who were given local treatment. Age, sex, height and weight of the patients were recorded, and the body mass index (BMI) was calculated. The hamstring and quadriceps muscle strengths of the non-dominant side were evaluated in all patients using an isokinetic dynamometer, and the peak torque (PT) values ​​were recorded. In the isotretinoin group, isokinetic measurements were performed again in those that completed six-month drug treatment and compared with the initial PT values. RESULTS: The two groups were similar in terms of age, sex, and BMI (p > 0.05). There was no significant difference between the isotretinoin and control groups in terms of muscle strength at the beginning of the treatment (p > 0.05). No significant change was observed in hamstring and quadriceps PT values in the isotretinoin group after 6 months of treatment compared to baseline (p > 0.05). No statistically significant correlation was found between the serum CPK level and hamstring and quadriceps muscle strength (p > 0.05). CONCLUSION: Oral isotretinoin doesn’t alter muscle strength. There is no relationship between the serum CPK levels and muscle strength.
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spelling pubmed-79818912021-03-22 Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study Mülkoğlu, Cevriye Karaosmanoğlu, Nermin BMC Pharmacol Toxicol Research Article BACKGROUND: Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whether there was a correlation between the serum creatine phosphokinase (CPK) level, a specific marker of muscle breakdown, and muscle strength. METHODS: This study included 30 patients who presented to our hospital and were started on oral isotretinoin treatment for acne vulgaris and 30 patients in the control group who were given local treatment. Age, sex, height and weight of the patients were recorded, and the body mass index (BMI) was calculated. The hamstring and quadriceps muscle strengths of the non-dominant side were evaluated in all patients using an isokinetic dynamometer, and the peak torque (PT) values ​​were recorded. In the isotretinoin group, isokinetic measurements were performed again in those that completed six-month drug treatment and compared with the initial PT values. RESULTS: The two groups were similar in terms of age, sex, and BMI (p > 0.05). There was no significant difference between the isotretinoin and control groups in terms of muscle strength at the beginning of the treatment (p > 0.05). No significant change was observed in hamstring and quadriceps PT values in the isotretinoin group after 6 months of treatment compared to baseline (p > 0.05). No statistically significant correlation was found between the serum CPK level and hamstring and quadriceps muscle strength (p > 0.05). CONCLUSION: Oral isotretinoin doesn’t alter muscle strength. There is no relationship between the serum CPK levels and muscle strength. BioMed Central 2021-03-20 /pmc/articles/PMC7981891/ /pubmed/33743831 http://dx.doi.org/10.1186/s40360-021-00483-0 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Mülkoğlu, Cevriye
Karaosmanoğlu, Nermin
Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
title Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
title_full Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
title_fullStr Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
title_full_unstemmed Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
title_short Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
title_sort effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981891/
https://www.ncbi.nlm.nih.gov/pubmed/33743831
http://dx.doi.org/10.1186/s40360-021-00483-0
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