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Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model

OBJECTIVES: The objective of the study is to determine a parameter on the time-intensity curve (TIC) of dynamic contrast-enhanced ultrasonography (DCE-US) that best correlates with tumor growth and to evaluate whether the parameter could correlate with the early response to irinotecan in a rat liver...

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Autores principales: Taiji, Ryosuke, Nishiofuku, Hideyuki, Tanaka, Toshihiro, Minamiguchi, Kiyoyuki, Fukuoka, Yasushi, Saito, Natsuhiko, Taguchi, Hidehiko, Matsumoto, Takeshi, Marugami, Nagaaki, Hirai, Toshiko, Kichikawa, Kimihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981939/
https://www.ncbi.nlm.nih.gov/pubmed/33767907
http://dx.doi.org/10.25259/JCIS_6_2020
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author Taiji, Ryosuke
Nishiofuku, Hideyuki
Tanaka, Toshihiro
Minamiguchi, Kiyoyuki
Fukuoka, Yasushi
Saito, Natsuhiko
Taguchi, Hidehiko
Matsumoto, Takeshi
Marugami, Nagaaki
Hirai, Toshiko
Kichikawa, Kimihiko
author_facet Taiji, Ryosuke
Nishiofuku, Hideyuki
Tanaka, Toshihiro
Minamiguchi, Kiyoyuki
Fukuoka, Yasushi
Saito, Natsuhiko
Taguchi, Hidehiko
Matsumoto, Takeshi
Marugami, Nagaaki
Hirai, Toshiko
Kichikawa, Kimihiko
author_sort Taiji, Ryosuke
collection PubMed
description OBJECTIVES: The objective of the study is to determine a parameter on the time-intensity curve (TIC) of dynamic contrast-enhanced ultrasonography (DCE-US) that best correlates with tumor growth and to evaluate whether the parameter could correlate with the early response to irinotecan in a rat liver tumor model. MATERIAL AND METHODS: Twenty rats with tumors were evaluated (control: Saline, n = 6; treatment: Irinotecan, n = 14) regarding four parameters from TIC: Peak intensity (PI), k value, slope (PI × k), and time to peak (TTP). Relative changes in maximum tumor diameter between day 0 and 10, and parameters in the first 3 days were evaluated. The Mann-Whitney U-test was used to compare differences in tumor size and other parameters. Pearson’s correlation coefficients (r) between tumor size and parameters in the control group were calculated. In the treatment group, relative changes of parameters in the first 3 days were compared between responder and non-responder (<20% and ≥20% increase in size on day 10, respectively). RESULTS: PI, k value, PI × k, and TTP significantly correlated with tumor growth (r = 0.513, 0.911, 0.665, and 0.741, respectively). The mean RC in k value among responders (n = 6) was significantly lower than non-responders (n = 8) (mean k value, 4.96 vs. 72.5; P = 0.003). CONCLUSION: Parameters of DCE-US could be a useful parameter for identifying early response to irinotecan.
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spelling pubmed-79819392021-03-24 Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model Taiji, Ryosuke Nishiofuku, Hideyuki Tanaka, Toshihiro Minamiguchi, Kiyoyuki Fukuoka, Yasushi Saito, Natsuhiko Taguchi, Hidehiko Matsumoto, Takeshi Marugami, Nagaaki Hirai, Toshiko Kichikawa, Kimihiko J Clin Imaging Sci Original Research OBJECTIVES: The objective of the study is to determine a parameter on the time-intensity curve (TIC) of dynamic contrast-enhanced ultrasonography (DCE-US) that best correlates with tumor growth and to evaluate whether the parameter could correlate with the early response to irinotecan in a rat liver tumor model. MATERIAL AND METHODS: Twenty rats with tumors were evaluated (control: Saline, n = 6; treatment: Irinotecan, n = 14) regarding four parameters from TIC: Peak intensity (PI), k value, slope (PI × k), and time to peak (TTP). Relative changes in maximum tumor diameter between day 0 and 10, and parameters in the first 3 days were evaluated. The Mann-Whitney U-test was used to compare differences in tumor size and other parameters. Pearson’s correlation coefficients (r) between tumor size and parameters in the control group were calculated. In the treatment group, relative changes of parameters in the first 3 days were compared between responder and non-responder (<20% and ≥20% increase in size on day 10, respectively). RESULTS: PI, k value, PI × k, and TTP significantly correlated with tumor growth (r = 0.513, 0.911, 0.665, and 0.741, respectively). The mean RC in k value among responders (n = 6) was significantly lower than non-responders (n = 8) (mean k value, 4.96 vs. 72.5; P = 0.003). CONCLUSION: Parameters of DCE-US could be a useful parameter for identifying early response to irinotecan. Scientific Scholar 2021-03-15 /pmc/articles/PMC7981939/ /pubmed/33767907 http://dx.doi.org/10.25259/JCIS_6_2020 Text en © 2021 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Research
Taiji, Ryosuke
Nishiofuku, Hideyuki
Tanaka, Toshihiro
Minamiguchi, Kiyoyuki
Fukuoka, Yasushi
Saito, Natsuhiko
Taguchi, Hidehiko
Matsumoto, Takeshi
Marugami, Nagaaki
Hirai, Toshiko
Kichikawa, Kimihiko
Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
title Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
title_full Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
title_fullStr Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
title_full_unstemmed Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
title_short Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
title_sort useful parameters in dynamic contrast-enhanced ultrasonography for identifying early response to chemotherapy in a rat liver tumor model
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981939/
https://www.ncbi.nlm.nih.gov/pubmed/33767907
http://dx.doi.org/10.25259/JCIS_6_2020
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