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Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy

The platelet-albumin-bilirubin (PALBI) grade plays critical role in evaluating liver function. However, the change of PALBI grade from the preoperative to postoperative period in predicting patient outcomes after hepatectomy remains unclear. A total of 489 HCC patients who underwent hepatectomy in W...

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Autores principales: Wang, Zheng-Xia, Peng, Wei, Zhang, Xiao-Yun, Wen, Tian-Fu, Li, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982202/
https://www.ncbi.nlm.nih.gov/pubmed/33725934
http://dx.doi.org/10.1097/MD.0000000000024476
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author Wang, Zheng-Xia
Peng, Wei
Zhang, Xiao-Yun
Wen, Tian-Fu
Li, Chuan
author_facet Wang, Zheng-Xia
Peng, Wei
Zhang, Xiao-Yun
Wen, Tian-Fu
Li, Chuan
author_sort Wang, Zheng-Xia
collection PubMed
description The platelet-albumin-bilirubin (PALBI) grade plays critical role in evaluating liver function. However, the change of PALBI grade from the preoperative to postoperative period in predicting patient outcomes after hepatectomy remains unclear. A total of 489 HCC patients who underwent hepatectomy in West China Hospital between January, 2010 and June, 2016 were analyzed retrospectively.ΔPALBI grade was calculated by PALBI grade at the first postoperative month - preoperative PALBI grade.ΔPALBI >0 was considered as stable; otherwise, worse PALBI grade was considered. Kaplan– Meier method and Cox proportional hazard regression analyses were performed for survival analysis. Prognostic model was constructed by nomogram method. Three hundred forty two patients and 147 patients were classified into training group and validation group, respectively. In the training group, results from Cox model suggested that worse PALBI grade (HR 1.328, 95% CI 1.010–1.746, P = .042), tumor size (HR 1.460, 95% CI 1.058–2.015, P = .021), microvascular invasion (MVI, HR 1.802, 95% CI 1.205–2.695, P < .001), and high alpha-fetoprotein level (AFP, HR 1.364, 95% CI 1.044–1.781, P = .023) negatively influenced postoperative recurrence. Similarly, worse PALBI grade (HR 1.403, 95% CI 1.020–1.930, P = .038), tumor size (HR 1.708, 95% CI 1.157–2.520, P = .007), MVI (HR 1.914, 95% CI 1.375–2.663, P < .001), and presence of cirrhosis (HR 1.773, 95% CI 1.226–2.564, P = .002) had negatively impacts on overall survival. Patients with worse PALBI grade had worse recurrence free (RFS) and overall survival (OS). The prognostic model incorporating the change of PALBI grade constructed in training group and tested in the validation group could perform well in predicting the outcomes. Postoperative change of PALBI grade was independently risk factor related with prognosis. Prognostic model incorporating the change of PALBI grade might be a useful index to predict the prognosis of HCC patients following hepatectomy.
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spelling pubmed-79822022021-03-23 Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy Wang, Zheng-Xia Peng, Wei Zhang, Xiao-Yun Wen, Tian-Fu Li, Chuan Medicine (Baltimore) 7100 The platelet-albumin-bilirubin (PALBI) grade plays critical role in evaluating liver function. However, the change of PALBI grade from the preoperative to postoperative period in predicting patient outcomes after hepatectomy remains unclear. A total of 489 HCC patients who underwent hepatectomy in West China Hospital between January, 2010 and June, 2016 were analyzed retrospectively.ΔPALBI grade was calculated by PALBI grade at the first postoperative month - preoperative PALBI grade.ΔPALBI >0 was considered as stable; otherwise, worse PALBI grade was considered. Kaplan– Meier method and Cox proportional hazard regression analyses were performed for survival analysis. Prognostic model was constructed by nomogram method. Three hundred forty two patients and 147 patients were classified into training group and validation group, respectively. In the training group, results from Cox model suggested that worse PALBI grade (HR 1.328, 95% CI 1.010–1.746, P = .042), tumor size (HR 1.460, 95% CI 1.058–2.015, P = .021), microvascular invasion (MVI, HR 1.802, 95% CI 1.205–2.695, P < .001), and high alpha-fetoprotein level (AFP, HR 1.364, 95% CI 1.044–1.781, P = .023) negatively influenced postoperative recurrence. Similarly, worse PALBI grade (HR 1.403, 95% CI 1.020–1.930, P = .038), tumor size (HR 1.708, 95% CI 1.157–2.520, P = .007), MVI (HR 1.914, 95% CI 1.375–2.663, P < .001), and presence of cirrhosis (HR 1.773, 95% CI 1.226–2.564, P = .002) had negatively impacts on overall survival. Patients with worse PALBI grade had worse recurrence free (RFS) and overall survival (OS). The prognostic model incorporating the change of PALBI grade constructed in training group and tested in the validation group could perform well in predicting the outcomes. Postoperative change of PALBI grade was independently risk factor related with prognosis. Prognostic model incorporating the change of PALBI grade might be a useful index to predict the prognosis of HCC patients following hepatectomy. Lippincott Williams & Wilkins 2021-03-19 /pmc/articles/PMC7982202/ /pubmed/33725934 http://dx.doi.org/10.1097/MD.0000000000024476 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 7100
Wang, Zheng-Xia
Peng, Wei
Zhang, Xiao-Yun
Wen, Tian-Fu
Li, Chuan
Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy
title Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy
title_full Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy
title_fullStr Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy
title_full_unstemmed Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy
title_short Prognostic significance of postoperative change of PALBI grade for patients with hepatocellular carcinoma after hepatectomy
title_sort prognostic significance of postoperative change of palbi grade for patients with hepatocellular carcinoma after hepatectomy
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982202/
https://www.ncbi.nlm.nih.gov/pubmed/33725934
http://dx.doi.org/10.1097/MD.0000000000024476
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