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The epidemiology of myasthenia gravis
Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presenc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982252/ https://www.ncbi.nlm.nih.gov/pubmed/33767779 http://dx.doi.org/10.25122/jml-2020-0145 |
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author | Bubuioc, Ana-Maria Kudebayeva, Aigerim Turuspekova, Saule Lisnic, Vitalie Leone, Maurizio Angelo |
author_facet | Bubuioc, Ana-Maria Kudebayeva, Aigerim Turuspekova, Saule Lisnic, Vitalie Leone, Maurizio Angelo |
author_sort | Bubuioc, Ana-Maria |
collection | PubMed |
description | Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data available. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities. |
format | Online Article Text |
id | pubmed-7982252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-79822522021-03-24 The epidemiology of myasthenia gravis Bubuioc, Ana-Maria Kudebayeva, Aigerim Turuspekova, Saule Lisnic, Vitalie Leone, Maurizio Angelo J Med Life Review Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data available. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities. Carol Davila University Press 2021 /pmc/articles/PMC7982252/ /pubmed/33767779 http://dx.doi.org/10.25122/jml-2020-0145 Text en ©2021 JOURNAL of MEDICINE and LIFE This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Bubuioc, Ana-Maria Kudebayeva, Aigerim Turuspekova, Saule Lisnic, Vitalie Leone, Maurizio Angelo The epidemiology of myasthenia gravis |
title | The epidemiology of myasthenia gravis |
title_full | The epidemiology of myasthenia gravis |
title_fullStr | The epidemiology of myasthenia gravis |
title_full_unstemmed | The epidemiology of myasthenia gravis |
title_short | The epidemiology of myasthenia gravis |
title_sort | epidemiology of myasthenia gravis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982252/ https://www.ncbi.nlm.nih.gov/pubmed/33767779 http://dx.doi.org/10.25122/jml-2020-0145 |
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