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The epidemiology of myasthenia gravis

Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presenc...

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Autores principales: Bubuioc, Ana-Maria, Kudebayeva, Aigerim, Turuspekova, Saule, Lisnic, Vitalie, Leone, Maurizio Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982252/
https://www.ncbi.nlm.nih.gov/pubmed/33767779
http://dx.doi.org/10.25122/jml-2020-0145
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author Bubuioc, Ana-Maria
Kudebayeva, Aigerim
Turuspekova, Saule
Lisnic, Vitalie
Leone, Maurizio Angelo
author_facet Bubuioc, Ana-Maria
Kudebayeva, Aigerim
Turuspekova, Saule
Lisnic, Vitalie
Leone, Maurizio Angelo
author_sort Bubuioc, Ana-Maria
collection PubMed
description Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data available. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities.
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spelling pubmed-79822522021-03-24 The epidemiology of myasthenia gravis Bubuioc, Ana-Maria Kudebayeva, Aigerim Turuspekova, Saule Lisnic, Vitalie Leone, Maurizio Angelo J Med Life Review Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data available. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities. Carol Davila University Press 2021 /pmc/articles/PMC7982252/ /pubmed/33767779 http://dx.doi.org/10.25122/jml-2020-0145 Text en ©2021 JOURNAL of MEDICINE and LIFE This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Bubuioc, Ana-Maria
Kudebayeva, Aigerim
Turuspekova, Saule
Lisnic, Vitalie
Leone, Maurizio Angelo
The epidemiology of myasthenia gravis
title The epidemiology of myasthenia gravis
title_full The epidemiology of myasthenia gravis
title_fullStr The epidemiology of myasthenia gravis
title_full_unstemmed The epidemiology of myasthenia gravis
title_short The epidemiology of myasthenia gravis
title_sort epidemiology of myasthenia gravis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982252/
https://www.ncbi.nlm.nih.gov/pubmed/33767779
http://dx.doi.org/10.25122/jml-2020-0145
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