Cargando…
Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RE...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982286/ https://www.ncbi.nlm.nih.gov/pubmed/33438022 http://dx.doi.org/10.1093/eurheartj/ehaa953 |
_version_ | 1783667689536880640 |
---|---|
author | Csengeri, Dora Sprünker, Ngoc-Anh Di Castelnuovo, Augusto Niiranen, Teemu Vishram-Nielsen, Julie Kk Costanzo, Simona Söderberg, Stefan Jensen, Steen M Vartiainen, Erkki Donati, Maria Benedetta Magnussen, Christina Camen, Stephan Gianfagna, Francesco Løchen, Maja-Lisa Kee, Frank Kontto, Jukka Mathiesen, Ellisiv B Koenig, Wolfgang Blankenberg, Stefan de Gaetano, Giovanni Jørgensen, Torben Kuulasmaa, Kari Zeller, Tanja Salomaa, Veikko Iacoviello, Licia Schnabel, Renate B |
author_facet | Csengeri, Dora Sprünker, Ngoc-Anh Di Castelnuovo, Augusto Niiranen, Teemu Vishram-Nielsen, Julie Kk Costanzo, Simona Söderberg, Stefan Jensen, Steen M Vartiainen, Erkki Donati, Maria Benedetta Magnussen, Christina Camen, Stephan Gianfagna, Francesco Løchen, Maja-Lisa Kee, Frank Kontto, Jukka Mathiesen, Ellisiv B Koenig, Wolfgang Blankenberg, Stefan de Gaetano, Giovanni Jørgensen, Torben Kuulasmaa, Kari Zeller, Tanja Salomaa, Veikko Iacoviello, Licia Schnabel, Renate B |
author_sort | Csengeri, Dora |
collection | PubMed |
description | AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS : In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11–1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF. CONCLUSIONS : In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention. |
format | Online Article Text |
id | pubmed-7982286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-79822862021-03-24 Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes Csengeri, Dora Sprünker, Ngoc-Anh Di Castelnuovo, Augusto Niiranen, Teemu Vishram-Nielsen, Julie Kk Costanzo, Simona Söderberg, Stefan Jensen, Steen M Vartiainen, Erkki Donati, Maria Benedetta Magnussen, Christina Camen, Stephan Gianfagna, Francesco Løchen, Maja-Lisa Kee, Frank Kontto, Jukka Mathiesen, Ellisiv B Koenig, Wolfgang Blankenberg, Stefan de Gaetano, Giovanni Jørgensen, Torben Kuulasmaa, Kari Zeller, Tanja Salomaa, Veikko Iacoviello, Licia Schnabel, Renate B Eur Heart J Clnical Research AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS : In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11–1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF. CONCLUSIONS : In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention. Oxford University Press 2021-01-13 /pmc/articles/PMC7982286/ /pubmed/33438022 http://dx.doi.org/10.1093/eurheartj/ehaa953 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clnical Research Csengeri, Dora Sprünker, Ngoc-Anh Di Castelnuovo, Augusto Niiranen, Teemu Vishram-Nielsen, Julie Kk Costanzo, Simona Söderberg, Stefan Jensen, Steen M Vartiainen, Erkki Donati, Maria Benedetta Magnussen, Christina Camen, Stephan Gianfagna, Francesco Løchen, Maja-Lisa Kee, Frank Kontto, Jukka Mathiesen, Ellisiv B Koenig, Wolfgang Blankenberg, Stefan de Gaetano, Giovanni Jørgensen, Torben Kuulasmaa, Kari Zeller, Tanja Salomaa, Veikko Iacoviello, Licia Schnabel, Renate B Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
title | Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
title_full | Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
title_fullStr | Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
title_full_unstemmed | Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
title_short | Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
title_sort | alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes |
topic | Clnical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982286/ https://www.ncbi.nlm.nih.gov/pubmed/33438022 http://dx.doi.org/10.1093/eurheartj/ehaa953 |
work_keys_str_mv | AT csengeridora alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT sprunkerngocanh alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT dicastelnuovoaugusto alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT niiranenteemu alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT vishramnielsenjuliekk alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT costanzosimona alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT soderbergstefan alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT jensensteenm alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT vartiainenerkki alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT donatimariabenedetta alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT magnussenchristina alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT camenstephan alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT gianfagnafrancesco alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT løchenmajalisa alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT keefrank alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT konttojukka alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT mathiesenellisivb alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT koenigwolfgang alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT blankenbergstefan alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT degaetanogiovanni alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT jørgensentorben alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT kuulasmaakari alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT zellertanja alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT salomaaveikko alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT iacoviellolicia alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes AT schnabelrenateb alcoholconsumptioncardiacbiomarkersandriskofatrialfibrillationandadverseoutcomes |