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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RE...

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Autores principales: Csengeri, Dora, Sprünker, Ngoc-Anh, Di Castelnuovo, Augusto, Niiranen, Teemu, Vishram-Nielsen, Julie Kk, Costanzo, Simona, Söderberg, Stefan, Jensen, Steen M, Vartiainen, Erkki, Donati, Maria Benedetta, Magnussen, Christina, Camen, Stephan, Gianfagna, Francesco, Løchen, Maja-Lisa, Kee, Frank, Kontto, Jukka, Mathiesen, Ellisiv B, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Jørgensen, Torben, Kuulasmaa, Kari, Zeller, Tanja, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982286/
https://www.ncbi.nlm.nih.gov/pubmed/33438022
http://dx.doi.org/10.1093/eurheartj/ehaa953
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author Csengeri, Dora
Sprünker, Ngoc-Anh
Di Castelnuovo, Augusto
Niiranen, Teemu
Vishram-Nielsen, Julie Kk
Costanzo, Simona
Söderberg, Stefan
Jensen, Steen M
Vartiainen, Erkki
Donati, Maria Benedetta
Magnussen, Christina
Camen, Stephan
Gianfagna, Francesco
Løchen, Maja-Lisa
Kee, Frank
Kontto, Jukka
Mathiesen, Ellisiv B
Koenig, Wolfgang
Blankenberg, Stefan
de Gaetano, Giovanni
Jørgensen, Torben
Kuulasmaa, Kari
Zeller, Tanja
Salomaa, Veikko
Iacoviello, Licia
Schnabel, Renate B
author_facet Csengeri, Dora
Sprünker, Ngoc-Anh
Di Castelnuovo, Augusto
Niiranen, Teemu
Vishram-Nielsen, Julie Kk
Costanzo, Simona
Söderberg, Stefan
Jensen, Steen M
Vartiainen, Erkki
Donati, Maria Benedetta
Magnussen, Christina
Camen, Stephan
Gianfagna, Francesco
Løchen, Maja-Lisa
Kee, Frank
Kontto, Jukka
Mathiesen, Ellisiv B
Koenig, Wolfgang
Blankenberg, Stefan
de Gaetano, Giovanni
Jørgensen, Torben
Kuulasmaa, Kari
Zeller, Tanja
Salomaa, Veikko
Iacoviello, Licia
Schnabel, Renate B
author_sort Csengeri, Dora
collection PubMed
description AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS : In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11–1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF. CONCLUSIONS : In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.
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spelling pubmed-79822862021-03-24 Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes Csengeri, Dora Sprünker, Ngoc-Anh Di Castelnuovo, Augusto Niiranen, Teemu Vishram-Nielsen, Julie Kk Costanzo, Simona Söderberg, Stefan Jensen, Steen M Vartiainen, Erkki Donati, Maria Benedetta Magnussen, Christina Camen, Stephan Gianfagna, Francesco Løchen, Maja-Lisa Kee, Frank Kontto, Jukka Mathiesen, Ellisiv B Koenig, Wolfgang Blankenberg, Stefan de Gaetano, Giovanni Jørgensen, Torben Kuulasmaa, Kari Zeller, Tanja Salomaa, Veikko Iacoviello, Licia Schnabel, Renate B Eur Heart J Clnical Research AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS : In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11–1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF. CONCLUSIONS : In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention. Oxford University Press 2021-01-13 /pmc/articles/PMC7982286/ /pubmed/33438022 http://dx.doi.org/10.1093/eurheartj/ehaa953 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clnical Research
Csengeri, Dora
Sprünker, Ngoc-Anh
Di Castelnuovo, Augusto
Niiranen, Teemu
Vishram-Nielsen, Julie Kk
Costanzo, Simona
Söderberg, Stefan
Jensen, Steen M
Vartiainen, Erkki
Donati, Maria Benedetta
Magnussen, Christina
Camen, Stephan
Gianfagna, Francesco
Løchen, Maja-Lisa
Kee, Frank
Kontto, Jukka
Mathiesen, Ellisiv B
Koenig, Wolfgang
Blankenberg, Stefan
de Gaetano, Giovanni
Jørgensen, Torben
Kuulasmaa, Kari
Zeller, Tanja
Salomaa, Veikko
Iacoviello, Licia
Schnabel, Renate B
Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
title Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
title_full Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
title_fullStr Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
title_full_unstemmed Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
title_short Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
title_sort alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes
topic Clnical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982286/
https://www.ncbi.nlm.nih.gov/pubmed/33438022
http://dx.doi.org/10.1093/eurheartj/ehaa953
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