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Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis

AIMS : Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular effects of genetic mimicry of ANGPTL3 and ANGPTL4 inhibition and compare t...

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Detalles Bibliográficos
Autores principales:	Wang, Qin, Oliver-Williams, Clare, Raitakari, Olli T, Viikari, Jorma, Lehtimäki, Terho, Kähönen, Mika, Järvelin, Marjo-Riitta, Salomaa, Veikko, Perola, Markus, Danesh, John, Kettunen, Johannes, Butterworth, Adam S, Holmes, Michael V, Ala-Korpela, Mika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Clnical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982288/ https://www.ncbi.nlm.nih.gov/pubmed/33351885 http://dx.doi.org/10.1093/eurheartj/ehaa972

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