Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS

SARS-CoV 3C-like protease (3CL(pro)) is an attractive target for anti-severe acute respiratory syndrome (SARS) drug discovery, and its dimerization has been extensively proved to be indispensable for enzymatic activity. However, the reason why the dissociated monomer is inactive still remains unclea...

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Detalles Bibliográficos
Autores principales: Chen, Shuai, Hu, Tiancen, Zhang, Jian, Chen, Jing, Chen, Kaixian, Ding, Jianping, Jiang, Hualiang, Shen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2008
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982321/
https://www.ncbi.nlm.nih.gov/pubmed/17977841
http://dx.doi.org/10.1074/jbc.M705240200

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