Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report

BACKGROUND: Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against...

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Detalles Bibliográficos
Autores principales: Paul, Gilbert, Chad, Rudnick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982334/
https://www.ncbi.nlm.nih.gov/pubmed/33752624
http://dx.doi.org/10.1186/s12887-021-02618-y
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author Paul, Gilbert
Chad, Rudnick
author_facet Paul, Gilbert
Chad, Rudnick
author_sort Paul, Gilbert
collection PubMed
description BACKGROUND: Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. CASE PRESENTATION: A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth. CONCLUSION: Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
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spelling pubmed-79823342021-03-22 Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report Paul, Gilbert Chad, Rudnick BMC Pediatr Case Report BACKGROUND: Maternal vaccination for Influenza and Tetanus, Diphtheria, acellular Pertussis (TDaP) have been well studied in terms of safety and efficacy for protection of the newborn by placental passage of antibodies. Similar newborn protection would be expected after maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There is a significant and urgent need for research regarding safety and efficacy of vaccination against SARS-CoV-2 during pregnancy. CASE PRESENTATION: A vigorous, healthy, full-term female was born to a COVID-19 naïve mother who had received a single dose of messenger RNA (mRNA) vaccine for SARS-CoV-2 3 weeks prior to delivery. IgG cord blood antibodies were detected to SARS-CoV-2 at the time of birth. CONCLUSION: Here, we report the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination. BioMed Central 2021-03-22 /pmc/articles/PMC7982334/ /pubmed/33752624 http://dx.doi.org/10.1186/s12887-021-02618-y Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Paul, Gilbert
Chad, Rudnick
Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
title Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
title_full Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
title_fullStr Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
title_full_unstemmed Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
title_short Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report
title_sort newborn antibodies to sars-cov-2 detected in cord blood after maternal vaccination – a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982334/
https://www.ncbi.nlm.nih.gov/pubmed/33752624
http://dx.doi.org/10.1186/s12887-021-02618-y
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