Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum

LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously unnoticed phenotype: lrrkA KO cells exhibit enhanced...

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Detalles Bibliográficos
Autores principales: Bodinier, Romain, Sabra, Ayman, Leiba, Jade, Marchetti, Anna, Lamrabet, Otmane, Ayadi, Imen, Filić, Vedrana, Kawata, Takefumi, Weber, Igor, Cosson, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982419/
https://www.ncbi.nlm.nih.gov/pubmed/33763419
http://dx.doi.org/10.3389/fcell.2021.629200

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