Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication. However, the prohibitively low metabolic stabi...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Casey, Mary C., Vernekar, Sanjeev Kumar V., Sahani, Rajkumar Lalji, Kirby, Karen A., Du, Haijuan, Zhang, Huanchun, Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982424/
https://www.ncbi.nlm.nih.gov/pubmed/33777683
http://dx.doi.org/10.1016/j.apsb.2020.07.016

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