Cargando…

Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing

Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for treating melanoma, gastric cancer (GC) and bladder cancer with clinical benefit. Nevertheless, many patients failed to respond to anti-PD-1/PD-L1 treatment, so it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhiru, Kang, Wenting, Li, Ouwen, Qi, Fengyu, Wang, Junwei, You, Yinghua, He, Pengxing, Suo, Zhenhe, Zheng, Yichao, Liu, Hong-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982505/ https://www.ncbi.nlm.nih.gov/pubmed/33777676 http://dx.doi.org/10.1016/j.apsb.2020.11.005

Ejemplares similares

USP7: Novel Drug Target in Cancer Therapy
por: Wang, Zhiru, et al.
Publicado: (2019)

Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals
por: Ispasanie, Emma, et al.
Publicado: (2021)

Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma
por: He, Pengxing, et al.
Publicado: (2022)

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
por: Yang, Zhaojuan, et al.
Publicado: (2021)

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells
por: Wang, Yu, et al.
Publicado: (2020)

USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1
por: Das, Tanuza, et al.
Publicado: (2022)

USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells
por: Qian, Yu, et al.
Publicado: (2016)

Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8(+) T Cells and Causes Immunopathology in Response to Acute LCMV Infection
por: Friebus-Kardash, Justa, et al.
Publicado: (2023)

USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin
por: Qin, Tao, et al.
Publicado: (2021)

Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25
por: Valero, Rebeca, et al.
Publicado: (2001)

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
por: Schauer, Nathan J., et al.
Publicado: (2020)

PD-1 abrogates the prolonged persistence of CD8(+) CAR-T cells with 4-1BB co-stimulation
por: Li, Feng, et al.
Publicado: (2020)

Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin
por: Lee, Tak Gyeom, et al.
Publicado: (2023)

CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy
por: Bei, Yuncheng, et al.
Publicado: (2020)

Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade
por: Vackova, Julie, et al.
Publicado: (2020)

Downregulation of USP34 Inhibits the Growth and Migration of Pancreatic Cancer Cells via Inhibiting the PRR11
por: Lin, Changjie, et al.
Publicado: (2020)

TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS
por: Raina, Deepak, et al.
Publicado: (2013)

USP5 facilitates non-small cell lung cancer progression through stabilization of PD-L1
por: Pan, Jinghua, et al.
Publicado: (2021)

MicroRNA let-7a inhibits proliferation of breast cancer cell by downregulating USP32 expression
por: Liu, Chunyan, et al.
Publicado: (2019)

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma
por: Potu, Harish, et al.
Publicado: (2021)

Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients
por: Zhao, Chong, et al.
Publicado: (2021)

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma
por: Knatko, Elena V., et al.
Publicado: (2016)

Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity
por: Qiu, Meihua, et al.
Publicado: (2021)

Targeting STAT3 Abrogates Tim-3 Upregulation of Adaptive Resistance to PD-1 Blockade on Regulatory T Cells of Melanoma
por: Huang, Lili, et al.
Publicado: (2021)

Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation
por: Sun, Jiangang, et al.
Publicado: (2020)

A risk score combining co-expression modules related to myeloid cells and alternative splicing associates with response to PD-1/PD-L1 blockade in non-small cell lung cancer
por: Han, Yichao, et al.
Publicado: (2023)

Induction and abrogation of unresponsiveness in nude mouse cells
Publicado: (1976)

USP5 Promotes Uterine Corpus Endometrial Carcinoma Cell Growth and Migration via mTOR/4EBP1 Activation
por: Li, Yinghua, et al.
Publicado: (2021)

Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function
por: ZENG, SHAO-LIN, et al.
Publicado: (2015)

Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation
por: Olbryt, Magdalena, et al.
Publicado: (2017)

circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis
por: Yu, Jinling, et al.
Publicado: (2020)

Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619
por: Lavaud, Mélanie, et al.
Publicado: (2021)

Interferon β and Anti-PD-1/PD-L1 Checkpoint Blockade Cooperate in NK Cell-Mediated Killing of Nasopharyngeal Carcinoma Cells
por: Makowska, Anna, et al.
Publicado: (2019)

Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals
por: Muri, Lukas, et al.
Publicado: (2021)

USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1
por: Chen, Jin, et al.
Publicado: (2023)

Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER export
por: Chen, Fang-Fang, et al.
Publicado: (2020)

PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease
por: Duhalde Vega, Maite, et al.
Publicado: (2022)

Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes
por: Sun, Peng, et al.
Publicado: (2019)

4-1BB Agonism Combined With PD-L1 Blockade Increases the Number of Tissue-Resident CD8+ T Cells and Facilitates Tumor Abrogation
por: Qu, Qiu-xia, et al.
Publicado: (2020)

HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination
por: Li, T, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9te0kc87ulh8rc3v2s3j5dqg32