Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmiss...

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Detalles Bibliográficos
Autores principales: Zhang, Ju, Ding, Nan, Song, Yangzi, Song, Rui, Pan, Yang, Wang, Linghang, Yan, Shuo, Wang, Qi, Ma, Shanfang, Wei, Lirong, Yu, Fengting, Lu, Lianhe, Zhang, Fujie, Chen, Chen, Zeng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982642/
https://www.ncbi.nlm.nih.gov/pubmed/33778799
http://dx.doi.org/10.1016/j.xinn.2021.100099
Descripción
Sumario:SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.

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