Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmiss...

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Autores principales: Zhang, Ju, Ding, Nan, Song, Yangzi, Song, Rui, Pan, Yang, Wang, Linghang, Yan, Shuo, Wang, Qi, Ma, Shanfang, Wei, Lirong, Yu, Fengting, Lu, Lianhe, Zhang, Fujie, Chen, Chen, Zeng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982642/
https://www.ncbi.nlm.nih.gov/pubmed/33778799
http://dx.doi.org/10.1016/j.xinn.2021.100099
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author Zhang, Ju
Ding, Nan
Song, Yangzi
Song, Rui
Pan, Yang
Wang, Linghang
Yan, Shuo
Wang, Qi
Ma, Shanfang
Wei, Lirong
Yu, Fengting
Lu, Lianhe
Zhang, Fujie
Chen, Chen
Zeng, Hui
author_facet Zhang, Ju
Ding, Nan
Song, Yangzi
Song, Rui
Pan, Yang
Wang, Linghang
Yan, Shuo
Wang, Qi
Ma, Shanfang
Wei, Lirong
Yu, Fengting
Lu, Lianhe
Zhang, Fujie
Chen, Chen
Zeng, Hui
author_sort Zhang, Ju
collection PubMed
description SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.
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spelling pubmed-79826422021-03-23 Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak Zhang, Ju Ding, Nan Song, Yangzi Song, Rui Pan, Yang Wang, Linghang Yan, Shuo Wang, Qi Ma, Shanfang Wei, Lirong Yu, Fengting Lu, Lianhe Zhang, Fujie Chen, Chen Zeng, Hui Innovation (Camb) Report SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons. Elsevier 2021-03-22 /pmc/articles/PMC7982642/ /pubmed/33778799 http://dx.doi.org/10.1016/j.xinn.2021.100099 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Report
Zhang, Ju
Ding, Nan
Song, Yangzi
Song, Rui
Pan, Yang
Wang, Linghang
Yan, Shuo
Wang, Qi
Ma, Shanfang
Wei, Lirong
Yu, Fengting
Lu, Lianhe
Zhang, Fujie
Chen, Chen
Zeng, Hui
Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak
title Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak
title_full Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak
title_fullStr Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak
title_full_unstemmed Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak
title_short Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak
title_sort phylogenomic tracing of asymptomatic transmission in a covid-19 outbreak
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982642/
https://www.ncbi.nlm.nih.gov/pubmed/33778799
http://dx.doi.org/10.1016/j.xinn.2021.100099
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