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Autophagy in Viral Development and Progression of Cancer
Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982729/ https://www.ncbi.nlm.nih.gov/pubmed/33763351 http://dx.doi.org/10.3389/fonc.2021.603224 |
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author | Suares, Alejandra Medina, María Victoria Coso, Omar |
author_facet | Suares, Alejandra Medina, María Victoria Coso, Omar |
author_sort | Suares, Alejandra |
collection | PubMed |
description | Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells. |
format | Online Article Text |
id | pubmed-7982729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79827292021-03-23 Autophagy in Viral Development and Progression of Cancer Suares, Alejandra Medina, María Victoria Coso, Omar Front Oncol Oncology Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells. Frontiers Media S.A. 2021-03-08 /pmc/articles/PMC7982729/ /pubmed/33763351 http://dx.doi.org/10.3389/fonc.2021.603224 Text en Copyright © 2021 Suares, Medina and Coso http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Suares, Alejandra Medina, María Victoria Coso, Omar Autophagy in Viral Development and Progression of Cancer |
title | Autophagy in Viral Development and Progression of Cancer |
title_full | Autophagy in Viral Development and Progression of Cancer |
title_fullStr | Autophagy in Viral Development and Progression of Cancer |
title_full_unstemmed | Autophagy in Viral Development and Progression of Cancer |
title_short | Autophagy in Viral Development and Progression of Cancer |
title_sort | autophagy in viral development and progression of cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982729/ https://www.ncbi.nlm.nih.gov/pubmed/33763351 http://dx.doi.org/10.3389/fonc.2021.603224 |
work_keys_str_mv | AT suaresalejandra autophagyinviraldevelopmentandprogressionofcancer AT medinamariavictoria autophagyinviraldevelopmentandprogressionofcancer AT cosoomar autophagyinviraldevelopmentandprogressionofcancer |