Cargando…

Autophagy in Viral Development and Progression of Cancer

Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy...

Descripción completa

Detalles Bibliográficos
Autores principales: Suares, Alejandra, Medina, María Victoria, Coso, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982729/
https://www.ncbi.nlm.nih.gov/pubmed/33763351
http://dx.doi.org/10.3389/fonc.2021.603224
_version_ 1783667779939860480
author Suares, Alejandra
Medina, María Victoria
Coso, Omar
author_facet Suares, Alejandra
Medina, María Victoria
Coso, Omar
author_sort Suares, Alejandra
collection PubMed
description Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells.
format Online
Article
Text
id pubmed-7982729
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79827292021-03-23 Autophagy in Viral Development and Progression of Cancer Suares, Alejandra Medina, María Victoria Coso, Omar Front Oncol Oncology Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells. Frontiers Media S.A. 2021-03-08 /pmc/articles/PMC7982729/ /pubmed/33763351 http://dx.doi.org/10.3389/fonc.2021.603224 Text en Copyright © 2021 Suares, Medina and Coso http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Suares, Alejandra
Medina, María Victoria
Coso, Omar
Autophagy in Viral Development and Progression of Cancer
title Autophagy in Viral Development and Progression of Cancer
title_full Autophagy in Viral Development and Progression of Cancer
title_fullStr Autophagy in Viral Development and Progression of Cancer
title_full_unstemmed Autophagy in Viral Development and Progression of Cancer
title_short Autophagy in Viral Development and Progression of Cancer
title_sort autophagy in viral development and progression of cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982729/
https://www.ncbi.nlm.nih.gov/pubmed/33763351
http://dx.doi.org/10.3389/fonc.2021.603224
work_keys_str_mv AT suaresalejandra autophagyinviraldevelopmentandprogressionofcancer
AT medinamariavictoria autophagyinviraldevelopmentandprogressionofcancer
AT cosoomar autophagyinviraldevelopmentandprogressionofcancer