Cargando…

Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification

Recently, host whole blood gene expression signatures have been identified for diagnosis of tuberculosis (TB). Absolute quantification of the concentrations of signature transcripts in blood have not been reported, but would facilitate diagnostic test development. To identify minimal transcript sign...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gliddon, Harriet D., Kaforou, Myrsini, Alikian, Mary, Habgood-Coote, Dominic, Zhou, Chenxi, Oni, Tolu, Anderson, Suzanne T., Brent, Andrew J., Crampin, Amelia C., Eley, Brian, Heyderman, Robert, Kern, Florian, Langford, Paul R., Ottenhoff, Tom H. M., Hibberd, Martin L., French, Neil, Wright, Victoria J., Dockrell, Hazel M., Coin, Lachlan J., Wilkinson, Robert J., Levin, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982854/ https://www.ncbi.nlm.nih.gov/pubmed/33763081 http://dx.doi.org/10.3389/fimmu.2021.637164

Ejemplares similares

Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study
por: Kaforou, Myrsini, et al.
Publicado: (2013)

Bioinformatics: living on the edge
por: Bellos, Evangelos, et al.
Publicado: (2012)

Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation
por: Gliddon, Harriet D., et al.
Publicado: (2017)

Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa
por: Morris, Thomas C., et al.
Publicado: (2021)

Sensitivity of shotgun metagenomics to host DNA: abundance estimates depend on bioinformatic tools and contamination is the main issue
por: McArdle, Andrew J., et al.
Publicado: (2020)

Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants’ Mimics Wild Type Infection
por: Gómez-Carballa, Alberto, et al.
Publicado: (2021)

2351. Systemic Influenza Infection Impairs Whole Blood Control of Mycobacteria in a Human Challenge Study
por: Broderick, Claire, et al.
Publicado: (2022)

Bridging a diagnostic Kawasaki disease classifier from a microarray platform to a qRT-PCR assay
por: Kuiper, Rowan, et al.
Publicado: (2022)

A proteomics-based method for identifying antigens within immune complexes
por: Menikou, Stephanie, et al.
Publicado: (2020)

Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus
por: Busse, D. C., et al.
Publicado: (2020)

Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature
por: Wright, Victoria J., et al.
Publicado: (2018)

Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function
por: Hemingway, Cheryl, et al.
Publicado: (2017)

A sputum sample processing method for community and mobile tuberculosis diagnosis using the Xpert MTB/RIF assay
por: Gliddon, Harriet D., et al.
Publicado: (2019)

Simulating the dynamics of targeted capture sequencing with CapSim
por: Cao, Minh Duc, et al.
Publicado: (2018)

Ongoing human chromosome end extension revealed by analysis of BioNano and nanopore data
por: Shao, Haojing, et al.
Publicado: (2018)

Combination of Cytokine Responses Indicative of Latent TB and Active TB in Malawian Adults
por: Hur, Yun-Gyoung, et al.
Publicado: (2013)

High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening
por: Oni, Tolu, et al.
Publicado: (2011)

Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa
por: Oni, Tolu, et al.
Publicado: (2012)

Understanding immune protection against tuberculosis using RNA expression profiling
por: von Both, Ulrich, et al.
Publicado: (2015)

Transcriptomics for child and adolescent tuberculosis
por: Kaforou, Myrsini, et al.
Publicado: (2022)

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria
por: Georgiadou, Athina, et al.
Publicado: (2022)

Why the communicable/non-communicable disease dichotomy is problematic for public health control strategies: implications of multimorbidity for health systems in an era of health transition
por: Oni, Tolu, et al.
Publicado: (2015)

A Systematised Review of the Health Impact of Urban Informal Settlements and Implications for Upgrading Interventions in South Africa, a Rapidly Urbanising Middle-Income Country
por: Weimann, Amy, et al.
Publicado: (2019)

The prevalence and determinants of active tuberculosis among diabetes patients in Cape Town, South Africa, a high HIV/TB burden setting
por: Berkowitz, Natacha, et al.
Publicado: (2018)

Trilateral overlap of tuberculosis, diabetes and HIV-1 in a high-burden African setting: implications for TB control
por: Oni, Tolu, et al.
Publicado: (2017)

Tuberculosis, Human Immunodeficiency Virus, and the Association With Transient Hyperglycemia in Periurban South Africa
por: Kubjane, Mmamapudi, et al.
Publicado: (2020)

Correction: Impairment of IFN-Gamma Response to Synthetic Peptides of Mycobacterium tuberculosis in a 7-Day Whole Blood Assay
por: Gideon, Hannah Priyadarshini, et al.
Publicado: (2013)

Impairment of IFN-Gamma Response to Synthetic Peptides of Mycobacterium tuberculosis in a 7-Day Whole Blood Assay
por: Gideon, Hannah Priyadarshini, et al.
Publicado: (2013)

Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study
por: Li, Ho Kwong, et al.
Publicado: (2021)

Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa- a cross sectional study
por: Oni, Tolu, et al.
Publicado: (2015)

QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response
por: Esmail, Hanif, et al.
Publicado: (2016)

Cardio-Thoracic Ratio Is Stable, Reproducible and Has Potential as a Screening Tool for HIV-1 Related Cardiac Disorders in Resource Poor Settings
por: Esmail, Hanif, et al.
Publicado: (2016)

Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individuals
por: Broderick, Claire, et al.
Publicado: (2021)

Comparative transcriptomic analysis of whole blood mycobacterial growth assays and tuberculosis patients’ blood RNA profiles
por: Bachanová, Petra, et al.
Publicado: (2022)

Characterisation of the blood RNA host response underpinning severity in COVID-19 patients
por: Jackson, Heather, et al.
Publicado: (2022)

A cross-sectional and spatial analysis of the prevalence of multimorbidity and its association with socioeconomic disadvantage in South Africa: A comparison between 2008 and 2012
por: Weimann, Amy, et al.
Publicado: (2016)

Missed opportunities for NCD multimorbidity prevention in adolescents and youth living with HIV in urban South Africa
por: Kamkuemah, Monika, et al.
Publicado: (2020)

Genome Wide Expression Profiling Reveals Suppression of Host Defence Responses during Colonisation by Neisseria meningitides but not N. lactamica
por: Wong, Hazel En En, et al.
Publicado: (2011)

cnvOffSeq: detecting intergenic copy number variation using off-target exome sequencing data
por: Bellos, Evangelos, et al.
Publicado: (2014)

Methodological challenges in measuring vaccine effectiveness using population cohorts in low resource settings
por: King, C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_16pmepedeumgjegqd2c5td8e2d