Cargando…

A More Homogeneous Phenotype in Parkinson's Disease Related to R1441G Mutation in the LRRK2 Gene

Parkinson's disease (PD) is characterized by a great clinical heterogeneity. Nevertheless, the biological drivers of this heterogeneity have not been completely elucidated and are likely to be complex, arising from interactions between genetic, epigenetic, and environmental factors. Despite thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vinagre-Aragón, Ana, Campo-Caballero, David, Mondragón-Rezola, Elisabet, Pardina-Vilella, Lara, Hernandez Eguiazu, Haizea, Gorostidi, Ana, Croitoru, Ioana, Bergareche, Alberto, Ruiz-Martinez, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982912/ https://www.ncbi.nlm.nih.gov/pubmed/33763016 http://dx.doi.org/10.3389/fneur.2021.635396

Ejemplares similares

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
por: Fan, Ying, et al.
Publicado: (2021)

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease
por: Gomes, Sara, et al.
Publicado: (2023)

LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity
por: Liu, Hui-Fang, et al.
Publicado: (2014)

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models
por: Williamson, Matthew G, et al.
Publicado: (2023)

Efficient Allele-Specific Targeting of LRRK2 R1441 Mutations Mediated by RNAi
por: de Yñigo-Mojado, Laura, et al.
Publicado: (2011)

Transgenic LRRK2(R1441G) rats–a model for Parkinson disease?
por: Shaikh, Komal T., et al.
Publicado: (2015)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment
por: Thomas, Joseph M., et al.
Publicado: (2017)

α-Synuclein Levels in Blood Plasma from LRRK2 Mutation Carriers
por: Gorostidi, Ana, et al.
Publicado: (2012)

R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
por: Xenias, Harry S., et al.
Publicado: (2022)

Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice
por: Feng, Yu-Kun, et al.
Publicado: (2020)

HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
por: Kim, Taewoo, et al.
Publicado: (2019)

Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations
por: Takanashi, Masashi, et al.
Publicado: (2018)

In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2(R1441G) mutant mouse model of Parkinson's disease
por: Ho, Philip Wing‐Lok, et al.
Publicado: (2023)

Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice
por: Sanchez, Gonzalo, et al.
Publicado: (2014)

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2(R1441G) mice
por: Liu, Huifang, et al.
Publicado: (2020)

Hypothyroidism in the “Arnolfini Portrait” (1434) by Jan Van Eyck (1390–1441)
por: Ashrafian, H.
Publicado: (2017)

Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls
por: Alvarez-Castelao, Beatriz, et al.
Publicado: (2014)

LRRK2 Phosphorylation, More Than an Epiphenomenon
por: Marchand, Antoine, et al.
Publicado: (2020)

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
por: López de Maturana, Rakel, et al.
Publicado: (2016)

Spectrum of heart diseases in a new cardiac service in Nigeria: An echocardiographic study of 1441 subjects in Abeokuta
por: Ogah, Okechukwu S, et al.
Publicado: (2008)

1441. Doses of 13-Valent Conjugated Pneumococcal Vaccine (PCV13) for Patients With Multiple Myeloma (MM)
por: Sun, Hsin-Yun, et al.
Publicado: (2018)

1441. Hand hygiene compliance in Brazil: from rich hospitals in the southwest to jungle hospitals - the big challenge
por: Couto, Braulio, et al.
Publicado: (2023)

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
por: Giesert, Florian, et al.
Publicado: (2013)

1441. Comparison of Cefpodoxime vs. Oral Cefuroxime for Urinary Tract Infections at a Large Academic Medical Center
por: Bao, Hongkai, et al.
Publicado: (2019)

PO-1441 Remote monitoring during radiotherapy – recruitment for an eHealth study under the Covid19 pandemic
por: Pappot, H., et al.
Publicado: (2022)

A Set of Reliable Samples for the Study of Biomarkers for the Early Diagnosis of Parkinson's Disease
por: Konjevod, Marcela, et al.
Publicado: (2022)

Quality of life in idiopathic dystonia: a systematic review
por: Girach, Ayesha, et al.
Publicado: (2018)

1441. Using Carbapenem Resistance Levels to Discriminate Between Carbapenemase Producing and Non-Carbapenemase Producing Carbapenem Resistant Enterobacteriaceae
por: Koehne, William J, et al.
Publicado: (2020)

P1441: REAL-WORLD OUTCOMES AND DIGITALLY MONITORED QUALITY OF LIFE IN CRIZANLIZUMAB-TREATED PATIENTS WITH SICKLE CELL DISEASE.
por: Summers, Kim, et al.
Publicado: (2023)

Dynamic and redundant regulation of LRRK2 and LRRK1 expression
por: Biskup, Saskia, et al.
Publicado: (2007)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

1441. LTBI screening cascade for non-US-born persons in a large health system assessed using EMR data
por: Shapiro, Adrienne E, et al.
Publicado: (2022)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2
por: Kuhlmann, Naila, et al.
Publicado: (2020)

Capturing the domain crosstalk in full length LRRK2 and LRRK2(RCKW)
por: Störmer, Eliza, et al.
Publicado: (2023)

Interplay of LRRK2 with chaperone-mediated autophagy
por: Orenstein, Samantha J., et al.
Publicado: (2013)

Movement Disorders Related to Gluten Sensitivity: A Systematic Review
por: Vinagre-Aragón, Ana, et al.
Publicado: (2018)

SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor
por: Sánchez, Elena, et al.
Publicado: (2015)

P1441: SINGLE-CELL TRANSCRIPTOMIC CHARACTERIZATIONS OF BONE MARROW MONONUCLEAR CELLS AND CAR-T PRODUCTS ASSOCIATED WITH EFFICACY AND TOXICITY IN B-ALL PATIENTS
por: Du, M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_42k2heb35vd3rujlnb4s7gcgc1