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Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives

Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus and an infectious disease that has caused fear among people across the world. The worldwide emergence and rapid expansion...

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Autores principales: Vivekanandhan, Karthik, Shanmugam, Poornima, Barabadi, Hamed, Arumugam, Vigneshwaran, Daniel Raj Daniel Paul Raj, Dharun, Sivasubramanian, Manikandan, Ramasamy, Subbaiya, Anand, Krishnan, Boomi, Pandi, Chandrasekaran, Balakumar, Arokiyaraj, Selvaraj, Saravanan, Muthupandian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983051/
https://www.ncbi.nlm.nih.gov/pubmed/33763450
http://dx.doi.org/10.3389/fmolb.2021.604447
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author Vivekanandhan, Karthik
Shanmugam, Poornima
Barabadi, Hamed
Arumugam, Vigneshwaran
Daniel Raj Daniel Paul Raj, Dharun
Sivasubramanian, Manikandan
Ramasamy, Subbaiya
Anand, Krishnan
Boomi, Pandi
Chandrasekaran, Balakumar
Arokiyaraj, Selvaraj
Saravanan, Muthupandian
author_facet Vivekanandhan, Karthik
Shanmugam, Poornima
Barabadi, Hamed
Arumugam, Vigneshwaran
Daniel Raj Daniel Paul Raj, Dharun
Sivasubramanian, Manikandan
Ramasamy, Subbaiya
Anand, Krishnan
Boomi, Pandi
Chandrasekaran, Balakumar
Arokiyaraj, Selvaraj
Saravanan, Muthupandian
author_sort Vivekanandhan, Karthik
collection PubMed
description Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus and an infectious disease that has caused fear among people across the world. The worldwide emergence and rapid expansion of SARS-CoV-2 emphasizes the need for exploring innovative therapeutic approaches to combat SARS-CoV-2. The efficacy of some antiviral drugs such as remdesivir, favipiravir, umifenovir, etc., are still tested against SARS-CoV-2. Additionally, there is a large global effort to develop vaccines for the protection against COVID-19. Because vaccines seem the best solution to control the pandemic but time is required for its development, pre-clinical/clinical trials, approval from FDA and scale-up. The nano-based approach is another promising approach to combat COVID-19 owing to unique physicochemical properties of nanomaterials. Peptide based vaccines emerged as promising vaccine candidates for SARS-CoV-2. The study emphasizes the current therapeutic approaches against SARS-CoV-2 and some of the potential candidates for SARS-CoV-2 treatment which are still under clinical studies for their effectiveness against SARS-CoV-2. Overall, it is of high importance to mention that clinical trials are necessary for confirming promising drug candidates and effective vaccines and the safety profile of the new components must be evaluated before translation of in vitro studies for implementation in clinical use.
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spelling pubmed-79830512021-03-23 Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives Vivekanandhan, Karthik Shanmugam, Poornima Barabadi, Hamed Arumugam, Vigneshwaran Daniel Raj Daniel Paul Raj, Dharun Sivasubramanian, Manikandan Ramasamy, Subbaiya Anand, Krishnan Boomi, Pandi Chandrasekaran, Balakumar Arokiyaraj, Selvaraj Saravanan, Muthupandian Front Mol Biosci Molecular Biosciences Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus and an infectious disease that has caused fear among people across the world. The worldwide emergence and rapid expansion of SARS-CoV-2 emphasizes the need for exploring innovative therapeutic approaches to combat SARS-CoV-2. The efficacy of some antiviral drugs such as remdesivir, favipiravir, umifenovir, etc., are still tested against SARS-CoV-2. Additionally, there is a large global effort to develop vaccines for the protection against COVID-19. Because vaccines seem the best solution to control the pandemic but time is required for its development, pre-clinical/clinical trials, approval from FDA and scale-up. The nano-based approach is another promising approach to combat COVID-19 owing to unique physicochemical properties of nanomaterials. Peptide based vaccines emerged as promising vaccine candidates for SARS-CoV-2. The study emphasizes the current therapeutic approaches against SARS-CoV-2 and some of the potential candidates for SARS-CoV-2 treatment which are still under clinical studies for their effectiveness against SARS-CoV-2. Overall, it is of high importance to mention that clinical trials are necessary for confirming promising drug candidates and effective vaccines and the safety profile of the new components must be evaluated before translation of in vitro studies for implementation in clinical use. Frontiers Media S.A. 2021-03-08 /pmc/articles/PMC7983051/ /pubmed/33763450 http://dx.doi.org/10.3389/fmolb.2021.604447 Text en Copyright © 2021 Vivekanandhan, Shanmugam, Barabadi, Arumugam, Daniel Raj Daniel Paul Raj, Sivasubramanian, Ramasamy, Anand, Boomi, Chandrasekaran, Arokiyaraj and Saravanan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Vivekanandhan, Karthik
Shanmugam, Poornima
Barabadi, Hamed
Arumugam, Vigneshwaran
Daniel Raj Daniel Paul Raj, Dharun
Sivasubramanian, Manikandan
Ramasamy, Subbaiya
Anand, Krishnan
Boomi, Pandi
Chandrasekaran, Balakumar
Arokiyaraj, Selvaraj
Saravanan, Muthupandian
Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives
title Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives
title_full Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives
title_fullStr Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives
title_full_unstemmed Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives
title_short Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives
title_sort emerging therapeutic approaches to combat covid-19: present status and future perspectives
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983051/
https://www.ncbi.nlm.nih.gov/pubmed/33763450
http://dx.doi.org/10.3389/fmolb.2021.604447
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