Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis

We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma v...

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Autores principales: Solanki, Archana, Singh, Ashutosh, Chauhan, Abhishek, Chandra, Tulika, Himanshu, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983145/
https://www.ncbi.nlm.nih.gov/pubmed/33767553
http://dx.doi.org/10.4103/ajts.AJTS_89_19
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author Solanki, Archana
Singh, Ashutosh
Chauhan, Abhishek
Chandra, Tulika
Himanshu, D
author_facet Solanki, Archana
Singh, Ashutosh
Chauhan, Abhishek
Chandra, Tulika
Himanshu, D
author_sort Solanki, Archana
collection PubMed
description We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hence TPE was stopped.
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spelling pubmed-79831452021-03-24 Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis Solanki, Archana Singh, Ashutosh Chauhan, Abhishek Chandra, Tulika Himanshu, D Asian J Transfus Sci Case Report We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hence TPE was stopped. Wolters Kluwer - Medknow 2020 2020-12-19 /pmc/articles/PMC7983145/ /pubmed/33767553 http://dx.doi.org/10.4103/ajts.AJTS_89_19 Text en Copyright: © 2020 Asian Journal of Transfusion Science http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Solanki, Archana
Singh, Ashutosh
Chauhan, Abhishek
Chandra, Tulika
Himanshu, D
Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
title Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
title_full Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
title_fullStr Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
title_full_unstemmed Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
title_short Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis
title_sort therapeutic plasma exchange: a life-saving modality in wegener's granulomatosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983145/
https://www.ncbi.nlm.nih.gov/pubmed/33767553
http://dx.doi.org/10.4103/ajts.AJTS_89_19
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