Cargando…

Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial

BACKGROUND AND AIMS: Appropriate premedication can optimise haemodynamics and hence surgical field visibility during endoscopic sinus surgery (ESS). This study aimed to compare the intraoperative effect of gabapentin 1200 mg versus bisoprolol 2.5 mg, given 2 hours before ESS. METHODS: Patients were...

Descripción completa

Detalles Bibliográficos
Autores principales: Elnakera, Abeer M, Wagdy, Maram H, Abd-Elgelyl, Aymen A, EL-Anwar, Mohamed W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983831/
https://www.ncbi.nlm.nih.gov/pubmed/33776086
http://dx.doi.org/10.4103/ija.IJA_619_20
_version_ 1783667949399179264
author Elnakera, Abeer M
Wagdy, Maram H
Abd-Elgelyl, Aymen A
EL-Anwar, Mohamed W
author_facet Elnakera, Abeer M
Wagdy, Maram H
Abd-Elgelyl, Aymen A
EL-Anwar, Mohamed W
author_sort Elnakera, Abeer M
collection PubMed
description BACKGROUND AND AIMS: Appropriate premedication can optimise haemodynamics and hence surgical field visibility during endoscopic sinus surgery (ESS). This study aimed to compare the intraoperative effect of gabapentin 1200 mg versus bisoprolol 2.5 mg, given 2 hours before ESS. METHODS: Patients were assigned into one of three groups. Patients of gabapentin group received preoperative oral gabapentin 1200 mg while, patients of bisoprolol and control groups received oral bisoprolol 2.5 mg and placebo respectively 2 hours before ESS. Primary outcome: reduction of blood loss and surgical field quality. Secondary outcome: haemodynamic control. mean arterial pressure (MAP) and heart rate (HR) were recorded as baseline, before and after induction of anaesthesia, at 1, 5, 10, 15 minutes after intubation and then every 15 minutes until the end of surgery. Data also included Fromm and Boezaart category scale (assessed every 15 min), intraoperative blood loss, surgeon satisfaction score, intraoperative anaesthetic/analgesic and vasoactive medications requirements. RESULTS: Out of 66 eligible patients, 60 patients completed the study. Intraoperative MAP and HR were significantly lower and more stable in gabapentin and bisoprolol groups compared to control group (p < 0.05). The volume of blood loss was significantly lower (p 0.000) and operative field was more visible in gabapentin and bisoprolol groups than those in control group (p 0.000). CONCLUSION: The beneficial effect of gabapentin 1200 mg on intraoperative haemodynamic control and surgical field visibility is comparable to that of bisoprolol 2.5 mg when either of them is given as a single oral dose 2 hours before ESS.
format Online
Article
Text
id pubmed-7983831
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-79838312021-03-25 Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial Elnakera, Abeer M Wagdy, Maram H Abd-Elgelyl, Aymen A EL-Anwar, Mohamed W Indian J Anaesth Original Article BACKGROUND AND AIMS: Appropriate premedication can optimise haemodynamics and hence surgical field visibility during endoscopic sinus surgery (ESS). This study aimed to compare the intraoperative effect of gabapentin 1200 mg versus bisoprolol 2.5 mg, given 2 hours before ESS. METHODS: Patients were assigned into one of three groups. Patients of gabapentin group received preoperative oral gabapentin 1200 mg while, patients of bisoprolol and control groups received oral bisoprolol 2.5 mg and placebo respectively 2 hours before ESS. Primary outcome: reduction of blood loss and surgical field quality. Secondary outcome: haemodynamic control. mean arterial pressure (MAP) and heart rate (HR) were recorded as baseline, before and after induction of anaesthesia, at 1, 5, 10, 15 minutes after intubation and then every 15 minutes until the end of surgery. Data also included Fromm and Boezaart category scale (assessed every 15 min), intraoperative blood loss, surgeon satisfaction score, intraoperative anaesthetic/analgesic and vasoactive medications requirements. RESULTS: Out of 66 eligible patients, 60 patients completed the study. Intraoperative MAP and HR were significantly lower and more stable in gabapentin and bisoprolol groups compared to control group (p < 0.05). The volume of blood loss was significantly lower (p 0.000) and operative field was more visible in gabapentin and bisoprolol groups than those in control group (p 0.000). CONCLUSION: The beneficial effect of gabapentin 1200 mg on intraoperative haemodynamic control and surgical field visibility is comparable to that of bisoprolol 2.5 mg when either of them is given as a single oral dose 2 hours before ESS. Wolters Kluwer - Medknow 2021-02 2021-02-10 /pmc/articles/PMC7983831/ /pubmed/33776086 http://dx.doi.org/10.4103/ija.IJA_619_20 Text en Copyright: © 2021 Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Elnakera, Abeer M
Wagdy, Maram H
Abd-Elgelyl, Aymen A
EL-Anwar, Mohamed W
Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial
title Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial
title_full Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial
title_fullStr Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial
title_full_unstemmed Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial
title_short Preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: A randomised controlled trial
title_sort preoperative gabapentin versus bisoprolol for haemodynamic and surgical field optimisation during endoscopic sinus surgery: a randomised controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983831/
https://www.ncbi.nlm.nih.gov/pubmed/33776086
http://dx.doi.org/10.4103/ija.IJA_619_20
work_keys_str_mv AT elnakeraabeerm preoperativegabapentinversusbisoprololforhaemodynamicandsurgicalfieldoptimisationduringendoscopicsinussurgeryarandomisedcontrolledtrial
AT wagdymaramh preoperativegabapentinversusbisoprololforhaemodynamicandsurgicalfieldoptimisationduringendoscopicsinussurgeryarandomisedcontrolledtrial
AT abdelgelylaymena preoperativegabapentinversusbisoprololforhaemodynamicandsurgicalfieldoptimisationduringendoscopicsinussurgeryarandomisedcontrolledtrial
AT elanwarmohamedw preoperativegabapentinversusbisoprololforhaemodynamicandsurgicalfieldoptimisationduringendoscopicsinussurgeryarandomisedcontrolledtrial