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Does thiamine protect the brain from iron overload and alcohol‐related dementia?
Alcohol‐related dementia (ARD) is a common and severe co‐morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983902/ https://www.ncbi.nlm.nih.gov/pubmed/32808749 http://dx.doi.org/10.1002/alz.12146 |
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author | Listabarth, Stephan König, Daniel Vyssoki, Benjamin Hametner, Simon |
author_facet | Listabarth, Stephan König, Daniel Vyssoki, Benjamin Hametner, Simon |
author_sort | Listabarth, Stephan |
collection | PubMed |
description | Alcohol‐related dementia (ARD) is a common and severe co‐morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood‐brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and neuroimaging studies, discussed in this article. To validate this hypothesis, translational studies focusing on brain iron homeostasis in AUD, as well as prospective clinical studies investigating prevalence and clinical impact of BIO in AUD, should be conducted. If proven right, this would change the understanding of ARD and may lead to novel therapeutic interventions in prevention and treatment of ARD. |
format | Online Article Text |
id | pubmed-7983902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79839022021-03-24 Does thiamine protect the brain from iron overload and alcohol‐related dementia? Listabarth, Stephan König, Daniel Vyssoki, Benjamin Hametner, Simon Alzheimers Dement Theoretical Articles Alcohol‐related dementia (ARD) is a common and severe co‐morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood‐brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and neuroimaging studies, discussed in this article. To validate this hypothesis, translational studies focusing on brain iron homeostasis in AUD, as well as prospective clinical studies investigating prevalence and clinical impact of BIO in AUD, should be conducted. If proven right, this would change the understanding of ARD and may lead to novel therapeutic interventions in prevention and treatment of ARD. John Wiley and Sons Inc. 2020-08-18 2020-11 /pmc/articles/PMC7983902/ /pubmed/32808749 http://dx.doi.org/10.1002/alz.12146 Text en © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Theoretical Articles Listabarth, Stephan König, Daniel Vyssoki, Benjamin Hametner, Simon Does thiamine protect the brain from iron overload and alcohol‐related dementia? |
title | Does thiamine protect the brain from iron overload and alcohol‐related dementia? |
title_full | Does thiamine protect the brain from iron overload and alcohol‐related dementia? |
title_fullStr | Does thiamine protect the brain from iron overload and alcohol‐related dementia? |
title_full_unstemmed | Does thiamine protect the brain from iron overload and alcohol‐related dementia? |
title_short | Does thiamine protect the brain from iron overload and alcohol‐related dementia? |
title_sort | does thiamine protect the brain from iron overload and alcohol‐related dementia? |
topic | Theoretical Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983902/ https://www.ncbi.nlm.nih.gov/pubmed/32808749 http://dx.doi.org/10.1002/alz.12146 |
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