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Does thiamine protect the brain from iron overload and alcohol‐related dementia?

Alcohol‐related dementia (ARD) is a common and severe co‐morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted...

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Detalles Bibliográficos
Autores principales: Listabarth, Stephan, König, Daniel, Vyssoki, Benjamin, Hametner, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983902/
https://www.ncbi.nlm.nih.gov/pubmed/32808749
http://dx.doi.org/10.1002/alz.12146
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author Listabarth, Stephan
König, Daniel
Vyssoki, Benjamin
Hametner, Simon
author_facet Listabarth, Stephan
König, Daniel
Vyssoki, Benjamin
Hametner, Simon
author_sort Listabarth, Stephan
collection PubMed
description Alcohol‐related dementia (ARD) is a common and severe co‐morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood‐brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and neuroimaging studies, discussed in this article. To validate this hypothesis, translational studies focusing on brain iron homeostasis in AUD, as well as prospective clinical studies investigating prevalence and clinical impact of BIO in AUD, should be conducted. If proven right, this would change the understanding of ARD and may lead to novel therapeutic interventions in prevention and treatment of ARD.
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spelling pubmed-79839022021-03-24 Does thiamine protect the brain from iron overload and alcohol‐related dementia? Listabarth, Stephan König, Daniel Vyssoki, Benjamin Hametner, Simon Alzheimers Dement Theoretical Articles Alcohol‐related dementia (ARD) is a common and severe co‐morbidity in alcohol use disorder (AUD). We propose brain iron overload (BIO) to be an important and previously neglected pathogenic process, accelerating cognitive decline in AUD. Furthermore, we suggest thiamine, which is frequently depleted in AUD, to be a key modulator in this process: Thiamine deficiency impairs the integrity of the blood‐brain barrier, thereby enabling iron to pass through and accumulate in the brain. This hypothesis is based on findings from animal, translational, and neuroimaging studies, discussed in this article. To validate this hypothesis, translational studies focusing on brain iron homeostasis in AUD, as well as prospective clinical studies investigating prevalence and clinical impact of BIO in AUD, should be conducted. If proven right, this would change the understanding of ARD and may lead to novel therapeutic interventions in prevention and treatment of ARD. John Wiley and Sons Inc. 2020-08-18 2020-11 /pmc/articles/PMC7983902/ /pubmed/32808749 http://dx.doi.org/10.1002/alz.12146 Text en © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Theoretical Articles
Listabarth, Stephan
König, Daniel
Vyssoki, Benjamin
Hametner, Simon
Does thiamine protect the brain from iron overload and alcohol‐related dementia?
title Does thiamine protect the brain from iron overload and alcohol‐related dementia?
title_full Does thiamine protect the brain from iron overload and alcohol‐related dementia?
title_fullStr Does thiamine protect the brain from iron overload and alcohol‐related dementia?
title_full_unstemmed Does thiamine protect the brain from iron overload and alcohol‐related dementia?
title_short Does thiamine protect the brain from iron overload and alcohol‐related dementia?
title_sort does thiamine protect the brain from iron overload and alcohol‐related dementia?
topic Theoretical Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983902/
https://www.ncbi.nlm.nih.gov/pubmed/32808749
http://dx.doi.org/10.1002/alz.12146
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