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IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans
Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells,...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983929/ https://www.ncbi.nlm.nih.gov/pubmed/33125710 http://dx.doi.org/10.1002/eji.202048706 |
| _version_ | 1783667966670274560 |
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| author | Wellington, Dannielle Yin, Zixi Abdel‐Haq, Adi Zhang, Liwei Forbester, Jessica Kite, Kerry Rajapaksa, Ushani Laurenson‐Schafer, Henry Makvandi‐Nejad, Shokouh Jin, Boquan Bowes, Emma Manoharan, Krishnageetha Maldonado‐Perez, David Verrill, Clare Humphreys, Ian R. Dong, Tao |
| author_facet | Wellington, Dannielle Yin, Zixi Abdel‐Haq, Adi Zhang, Liwei Forbester, Jessica Kite, Kerry Rajapaksa, Ushani Laurenson‐Schafer, Henry Makvandi‐Nejad, Shokouh Jin, Boquan Bowes, Emma Manoharan, Krishnageetha Maldonado‐Perez, David Verrill, Clare Humphreys, Ian R. Dong, Tao |
| author_sort | Wellington, Dannielle |
| collection | PubMed |
| description | Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells. [Image: see text] |
| format | Online Article Text |
| id | pubmed-7983929 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79839292021-03-24 IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans Wellington, Dannielle Yin, Zixi Abdel‐Haq, Adi Zhang, Liwei Forbester, Jessica Kite, Kerry Rajapaksa, Ushani Laurenson‐Schafer, Henry Makvandi‐Nejad, Shokouh Jin, Boquan Bowes, Emma Manoharan, Krishnageetha Maldonado‐Perez, David Verrill, Clare Humphreys, Ian R. Dong, Tao Eur J Immunol Letters to the Editor Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells. [Image: see text] John Wiley and Sons Inc. 2020-12-09 2021-03 /pmc/articles/PMC7983929/ /pubmed/33125710 http://dx.doi.org/10.1002/eji.202048706 Text en © 2020 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Letters to the Editor Wellington, Dannielle Yin, Zixi Abdel‐Haq, Adi Zhang, Liwei Forbester, Jessica Kite, Kerry Rajapaksa, Ushani Laurenson‐Schafer, Henry Makvandi‐Nejad, Shokouh Jin, Boquan Bowes, Emma Manoharan, Krishnageetha Maldonado‐Perez, David Verrill, Clare Humphreys, Ian R. Dong, Tao IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_full | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_fullStr | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_full_unstemmed | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_short | IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans |
| title_sort | ifitm3‐specific antibody reveals ifn preferences and slow ifn induction of the antiviral factor ifitm3 in humans |
| topic | Letters to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983929/ https://www.ncbi.nlm.nih.gov/pubmed/33125710 http://dx.doi.org/10.1002/eji.202048706 |
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