Identification of Glycochenodeoxycholate 3‐O‐Glucuronide and Glycodeoxycholate 3‐O‐Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers

The aim of this study was to investigate the sensitivity and specificity of endogenous glycochenodeoxycholate and glycodeoxycholate 3‐O‐glucuronides (GCDCA‐3G and GDCA‐3G) as substrates for organic anion transporting polypeptide 1B1 (OATP1B1) in humans. We measured fasting levels of plasma GCDCA‐3G...

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Detalles Bibliográficos
Autores principales: Neuvonen, Mikko, Hirvensalo, Päivi, Tornio, Aleksi, Rago, Brian, West, Mark, Lazzaro, Sarah, Mathialagan, Sumathy, Varma, Manthena, Cerny, Matthew A., Costales, Chester, Ramanathan, Ragu, Rodrigues, A. David, Niemi, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983942/
https://www.ncbi.nlm.nih.gov/pubmed/32961594
http://dx.doi.org/10.1002/cpt.2053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983942/
https://www.ncbi.nlm.nih.gov/pubmed/32961594
http://dx.doi.org/10.1002/cpt.2053

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