Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects

The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine D(2) receptor blockade in the basal ga...

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Detalles Bibliográficos
Autores principales: Bauer, Martin, Bamminger, Karsten, Pichler, Verena, Weber, Maria, Binder, Simon, Maier‐Salamon, Alexandra, Tahir, Ammar, Jäger, Walter, Haslacher, Helmuth, Tournier, Nicolas, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983943/
https://www.ncbi.nlm.nih.gov/pubmed/32966590
http://dx.doi.org/10.1002/cpt.2052

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