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MAIT cells, guardians of skin and mucosa?

Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis. These cells are particularly present in liver and blood but also populate mucosal sites including skin, oral, intestinal, res...

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Detalles Bibliográficos
Autores principales: Nel, Isabelle, Bertrand, Léo, Toubal, Amine, Lehuen, Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983967/
https://www.ncbi.nlm.nih.gov/pubmed/33753874
http://dx.doi.org/10.1038/s41385-021-00391-w
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author Nel, Isabelle
Bertrand, Léo
Toubal, Amine
Lehuen, Agnès
author_facet Nel, Isabelle
Bertrand, Léo
Toubal, Amine
Lehuen, Agnès
author_sort Nel, Isabelle
collection PubMed
description Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis. These cells are particularly present in liver and blood but also populate mucosal sites including skin, oral, intestinal, respiratory, and urogenital tracts that are in contact with the environment and microbiota of their host. Growing evidence suggests important involvement of MAIT cells in safeguarding the mucosa against external microbial threats. Simultaneously, mucosal MAIT cells have been implicated in immune and inflammatory pathologies affecting these organs. Here, we review the specificities of mucosal MAIT cells, their functions in the protection and maintenance of mucosal barriers, and their interactions with other mucosal cells.
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spelling pubmed-79839672021-03-23 MAIT cells, guardians of skin and mucosa? Nel, Isabelle Bertrand, Léo Toubal, Amine Lehuen, Agnès Mucosal Immunol Review Article Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis. These cells are particularly present in liver and blood but also populate mucosal sites including skin, oral, intestinal, respiratory, and urogenital tracts that are in contact with the environment and microbiota of their host. Growing evidence suggests important involvement of MAIT cells in safeguarding the mucosa against external microbial threats. Simultaneously, mucosal MAIT cells have been implicated in immune and inflammatory pathologies affecting these organs. Here, we review the specificities of mucosal MAIT cells, their functions in the protection and maintenance of mucosal barriers, and their interactions with other mucosal cells. Nature Publishing Group US 2021-03-22 2021 /pmc/articles/PMC7983967/ /pubmed/33753874 http://dx.doi.org/10.1038/s41385-021-00391-w Text en © The Author(s), under exclusive licence to Society for Mucosal Immunology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Nel, Isabelle
Bertrand, Léo
Toubal, Amine
Lehuen, Agnès
MAIT cells, guardians of skin and mucosa?
title MAIT cells, guardians of skin and mucosa?
title_full MAIT cells, guardians of skin and mucosa?
title_fullStr MAIT cells, guardians of skin and mucosa?
title_full_unstemmed MAIT cells, guardians of skin and mucosa?
title_short MAIT cells, guardians of skin and mucosa?
title_sort mait cells, guardians of skin and mucosa?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983967/
https://www.ncbi.nlm.nih.gov/pubmed/33753874
http://dx.doi.org/10.1038/s41385-021-00391-w
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