Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation

The diterpene spiroviolene, its diterpene synthase from Streptomyces violens and the experimentally determined terpene cyclisation mechanism were reported in 2017. Recently, the structure of spiroviolene was revised based on a total synthesis, with consequences for the cyclisation mechanism. Herein,...

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Detalles Bibliográficos
Autores principales: Xu, Houchao, Dickschat, Jeroen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983979/
https://www.ncbi.nlm.nih.gov/pubmed/33084237
http://dx.doi.org/10.1002/cbic.202000682
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author Xu, Houchao
Dickschat, Jeroen S.
author_facet Xu, Houchao
Dickschat, Jeroen S.
author_sort Xu, Houchao
collection PubMed
description The diterpene spiroviolene, its diterpene synthase from Streptomyces violens and the experimentally determined terpene cyclisation mechanism were reported in 2017. Recently, the structure of spiroviolene was revised based on a total synthesis, with consequences for the cyclisation mechanism. Herein, a reinvestigation of the terpene cyclisation to spiroviolene and the mass spectrometric fragmentation mechanism investigated by (13)C‐labelling experiments are presented.
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spelling pubmed-79839792021-03-24 Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation Xu, Houchao Dickschat, Jeroen S. Chembiochem Communications The diterpene spiroviolene, its diterpene synthase from Streptomyces violens and the experimentally determined terpene cyclisation mechanism were reported in 2017. Recently, the structure of spiroviolene was revised based on a total synthesis, with consequences for the cyclisation mechanism. Herein, a reinvestigation of the terpene cyclisation to spiroviolene and the mass spectrometric fragmentation mechanism investigated by (13)C‐labelling experiments are presented. John Wiley and Sons Inc. 2020-11-10 2021-03-02 /pmc/articles/PMC7983979/ /pubmed/33084237 http://dx.doi.org/10.1002/cbic.202000682 Text en © 2020 The Authors. ChemBiochem published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Xu, Houchao
Dickschat, Jeroen S.
Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation
title Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation
title_full Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation
title_fullStr Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation
title_full_unstemmed Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation
title_short Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations of Its Mass Spectrometric Fragmentation
title_sort revision of the cyclisation mechanism for the diterpene spiroviolene and investigations of its mass spectrometric fragmentation
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983979/
https://www.ncbi.nlm.nih.gov/pubmed/33084237
http://dx.doi.org/10.1002/cbic.202000682
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AT dickschatjeroens revisionofthecyclisationmechanismforthediterpenespirovioleneandinvestigationsofitsmassspectrometricfragmentation

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