Cargando…
Appended Aromatic Moieties in Flexible Bis‐3‐chloropiperidines Confer Tropism against Pancreatic Cancer Cells
Nitrogen mustards (NMs) are an old but still largely diffused class of anticancer drugs. However, spreading mechanisms of resistance undermine their efficacy and therapeutic applicability. To expand their antitumour value, we developed bis‐3‐chloropiperidines (B‐CePs), a new class of mustard‐based a...
Autores principales: | Carraro, Caterina, Helbing, Tim, Francke, Alexander, Zuravka, Ivonne, Sosic, Alice, De Franco, Michele, Gandin, Valentina, Gatto, Barbara, Göttlich, D. Richard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984046/ https://www.ncbi.nlm.nih.gov/pubmed/33200541 http://dx.doi.org/10.1002/cmdc.202000814 |
Ejemplares similares
-
Aromatic Linkers Unleash the Antiproliferative Potential of 3‐Chloropiperidines Against Pancreatic Cancer Cells
por: Helbing, Tim, et al.
Publicado: (2020) -
Behind the Mirror: Chirality Tunes the Reactivity
and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents
por: Carraro, Caterina, et al.
Publicado: (2019) -
In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction
por: Sosic, Alice, et al.
Publicado: (2022) -
Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein
por: Sosic, Alice, et al.
Publicado: (2021) -
Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties
por: Sosic, Alice, et al.
Publicado: (2022)