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Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

INTRODUCTION: Neuronal extracellular vesicle (nEV) tau and insulin signaling biomarkers may detect preclinical Alzheimer's disease and age‐associated cognitive decline. METHODS: This case‐control study used repeated serum samples from 73 cognitively declining and 73 stable Wisconsin Registry fo...

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Autores principales: Eren, Erden, Hunt, Jack F. V., Shardell, Michelle, Chawla, Sahil, Tran, Joyce, Gu, Jeffrey, Vogt, Nick M., Johnson, Sterling C., Bendlin, Barbara B., Kapogiannis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984100/
https://www.ncbi.nlm.nih.gov/pubmed/32588967
http://dx.doi.org/10.1002/alz.12130
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author Eren, Erden
Hunt, Jack F. V.
Shardell, Michelle
Chawla, Sahil
Tran, Joyce
Gu, Jeffrey
Vogt, Nick M.
Johnson, Sterling C.
Bendlin, Barbara B.
Kapogiannis, Dimitrios
author_facet Eren, Erden
Hunt, Jack F. V.
Shardell, Michelle
Chawla, Sahil
Tran, Joyce
Gu, Jeffrey
Vogt, Nick M.
Johnson, Sterling C.
Bendlin, Barbara B.
Kapogiannis, Dimitrios
author_sort Eren, Erden
collection PubMed
description INTRODUCTION: Neuronal extracellular vesicle (nEV) tau and insulin signaling biomarkers may detect preclinical Alzheimer's disease and age‐associated cognitive decline. METHODS: This case‐control study used repeated serum samples from 73 cognitively declining and 73 stable Wisconsin Registry for Alzheimer's Prevention participants (62.4 ± 6.3 years old). We immunocaptured nEVs; measured tau and insulin signaling biomarkers; and examined biomarker differences by group, their performance in group classification in training and test datasets (97, 49 individuals, respectively), and whether they predict cognitive performance change. RESULTS: Declining compared to stable individuals showed higher baseline total, p231‐, and p181‐tau with older age and higher annualized change for p‐IR and p‐IGF‐1R. Combining biomarkers classified decliners with 94% area under the curve (AUC), 86.0% sensitivity and 86.7% specificity, in training data, and 75% AUC, 71.4% sensitivity, and 77.3% specificity, in test data. Insulin biomarkers predicted cognitive performance change prospectively. DISCUSSION: Combining nEV biomarkers can identify individuals with age‐associated cognitive decline.
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spelling pubmed-79841002021-03-24 Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age Eren, Erden Hunt, Jack F. V. Shardell, Michelle Chawla, Sahil Tran, Joyce Gu, Jeffrey Vogt, Nick M. Johnson, Sterling C. Bendlin, Barbara B. Kapogiannis, Dimitrios Alzheimers Dement Featured Articles INTRODUCTION: Neuronal extracellular vesicle (nEV) tau and insulin signaling biomarkers may detect preclinical Alzheimer's disease and age‐associated cognitive decline. METHODS: This case‐control study used repeated serum samples from 73 cognitively declining and 73 stable Wisconsin Registry for Alzheimer's Prevention participants (62.4 ± 6.3 years old). We immunocaptured nEVs; measured tau and insulin signaling biomarkers; and examined biomarker differences by group, their performance in group classification in training and test datasets (97, 49 individuals, respectively), and whether they predict cognitive performance change. RESULTS: Declining compared to stable individuals showed higher baseline total, p231‐, and p181‐tau with older age and higher annualized change for p‐IR and p‐IGF‐1R. Combining biomarkers classified decliners with 94% area under the curve (AUC), 86.0% sensitivity and 86.7% specificity, in training data, and 75% AUC, 71.4% sensitivity, and 77.3% specificity, in test data. Insulin biomarkers predicted cognitive performance change prospectively. DISCUSSION: Combining nEV biomarkers can identify individuals with age‐associated cognitive decline. John Wiley and Sons Inc. 2020-06-26 2020-09 /pmc/articles/PMC7984100/ /pubmed/32588967 http://dx.doi.org/10.1002/alz.12130 Text en © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This article has been contributed to by US Government employees and their work is in the public domain in the USA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Featured Articles
Eren, Erden
Hunt, Jack F. V.
Shardell, Michelle
Chawla, Sahil
Tran, Joyce
Gu, Jeffrey
Vogt, Nick M.
Johnson, Sterling C.
Bendlin, Barbara B.
Kapogiannis, Dimitrios
Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
title Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
title_full Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
title_fullStr Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
title_full_unstemmed Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
title_short Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
title_sort extracellular vesicle biomarkers of alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
topic Featured Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984100/
https://www.ncbi.nlm.nih.gov/pubmed/32588967
http://dx.doi.org/10.1002/alz.12130
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