Circulating metabolites are associated with brain atrophy and white matter hyperintensities

INTRODUCTION: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). METHODS: We studied associations of 143 plasma‐based metabolites with MRI measures of brain and hipp...

Descripción completa

Detalles Bibliográficos
Autores principales: de Leeuw, Francisca A., Karamujić‐Čomić, Hata, Tijms, Betty M., Peeters, Carel F.W., Kester, Maartje I., Scheltens, Philip, Ahmad, Shahzad, Vojinovic, Dina, Adams, Hieab H.H., Hankemeier, Thomas, Bos, Daniel, van der Lugt, Aad, Vernooij, Meike W., Ikram, M. Arfan, Amin, Najaf, Barkhof, Frederik, Teunissen, Charlotte E., van Duijn, Cornelia M., van der Flier, Wiesje M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Featured Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984157/
https://www.ncbi.nlm.nih.gov/pubmed/32886448
http://dx.doi.org/10.1002/alz.12180
Descripción
Sumario:INTRODUCTION: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). METHODS: We studied associations of 143 plasma‐based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta‐analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. RESULTS: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. DISCUSSION: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

Ejemplares similares