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Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion

Perfluorooctanesulfonic acid (PFOS) is a perfluorinated compound used in many industrial and consumer products. It has been linked to a broad range of adverse effects in several species, including zebrafish (Danio rerio). The zebrafish embryo is a widely used vertebrate model to elucidate potential...

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Autores principales: Mylroie, J. Erik, Wilbanks, Mitchell S., Kimble, Ashley N., To, Kimberly T., Cox, Catherine S., McLeod, Sheila J., Gust, Kurt A., Moore, David W., Perkins, Edward J., Garcia‐Reyero, Natàlia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984204/
https://www.ncbi.nlm.nih.gov/pubmed/33044770
http://dx.doi.org/10.1002/etc.4899
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author Mylroie, J. Erik
Wilbanks, Mitchell S.
Kimble, Ashley N.
To, Kimberly T.
Cox, Catherine S.
McLeod, Sheila J.
Gust, Kurt A.
Moore, David W.
Perkins, Edward J.
Garcia‐Reyero, Natàlia
author_facet Mylroie, J. Erik
Wilbanks, Mitchell S.
Kimble, Ashley N.
To, Kimberly T.
Cox, Catherine S.
McLeod, Sheila J.
Gust, Kurt A.
Moore, David W.
Perkins, Edward J.
Garcia‐Reyero, Natàlia
author_sort Mylroie, J. Erik
collection PubMed
description Perfluorooctanesulfonic acid (PFOS) is a perfluorinated compound used in many industrial and consumer products. It has been linked to a broad range of adverse effects in several species, including zebrafish (Danio rerio). The zebrafish embryo is a widely used vertebrate model to elucidate potential adverse effects of chemicals because it is amenable to medium and high throughput. However, there is limited research on the full extent of the impact the chorion has on those effects. Results from the present study indicate that the presence of the chorion affected the timing and incidence of mortality as well as morphometric endpoints such as spinal curvature and swim bladder inflation in zebrafish embryos exposed to PFOS. Furthermore, removal of the chorion prior to exposure resulted in a lower threshold of sensitivity to PFOS for effects on transcriptional expression within the peroxisome proliferator–activated receptor (PPAR) nuclear signaling pathway. Perturbation of PPAR pathway gene expression can result in disruption of metabolic signaling and regulation, which can adversely affect development, energy availability, and survival. It can be concluded that removal of the chorion has significant effects on the timing and incidence of impacts associated with PFOS exposure, and more research is warranted to fully elucidate the protective role of the chorion and the critical timing of these events. Environ Toxicol Chem 2021;40:780–791. Published 2020. This article is a US Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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spelling pubmed-79842042021-03-24 Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion Mylroie, J. Erik Wilbanks, Mitchell S. Kimble, Ashley N. To, Kimberly T. Cox, Catherine S. McLeod, Sheila J. Gust, Kurt A. Moore, David W. Perkins, Edward J. Garcia‐Reyero, Natàlia Environ Toxicol Chem Environmental Toxicology Perfluorooctanesulfonic acid (PFOS) is a perfluorinated compound used in many industrial and consumer products. It has been linked to a broad range of adverse effects in several species, including zebrafish (Danio rerio). The zebrafish embryo is a widely used vertebrate model to elucidate potential adverse effects of chemicals because it is amenable to medium and high throughput. However, there is limited research on the full extent of the impact the chorion has on those effects. Results from the present study indicate that the presence of the chorion affected the timing and incidence of mortality as well as morphometric endpoints such as spinal curvature and swim bladder inflation in zebrafish embryos exposed to PFOS. Furthermore, removal of the chorion prior to exposure resulted in a lower threshold of sensitivity to PFOS for effects on transcriptional expression within the peroxisome proliferator–activated receptor (PPAR) nuclear signaling pathway. Perturbation of PPAR pathway gene expression can result in disruption of metabolic signaling and regulation, which can adversely affect development, energy availability, and survival. It can be concluded that removal of the chorion has significant effects on the timing and incidence of impacts associated with PFOS exposure, and more research is warranted to fully elucidate the protective role of the chorion and the critical timing of these events. Environ Toxicol Chem 2021;40:780–791. Published 2020. This article is a US Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. John Wiley and Sons Inc. 2020-12-14 2021-03 /pmc/articles/PMC7984204/ /pubmed/33044770 http://dx.doi.org/10.1002/etc.4899 Text en Published 2020. This article is a US Government work and is in the public domain in the USA. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Environmental Toxicology
Mylroie, J. Erik
Wilbanks, Mitchell S.
Kimble, Ashley N.
To, Kimberly T.
Cox, Catherine S.
McLeod, Sheila J.
Gust, Kurt A.
Moore, David W.
Perkins, Edward J.
Garcia‐Reyero, Natàlia
Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion
title Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion
title_full Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion
title_fullStr Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion
title_full_unstemmed Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion
title_short Perfluorooctanesulfonic Acid–Induced Toxicity on Zebrafish Embryos in the Presence or Absence of the Chorion
title_sort perfluorooctanesulfonic acid–induced toxicity on zebrafish embryos in the presence or absence of the chorion
topic Environmental Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984204/
https://www.ncbi.nlm.nih.gov/pubmed/33044770
http://dx.doi.org/10.1002/etc.4899
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