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The complex role of genetic background in shaping the effects of spontaneous and induced mutations
Spontaneous and induced mutations frequently show different phenotypic effects across genetically distinct individuals. It is generally appreciated that these background effects mainly result from genetic interactions between the mutations and segregating loci. However, the architectures and molecul...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984271/ https://www.ncbi.nlm.nih.gov/pubmed/33125810 http://dx.doi.org/10.1002/yea.3530 |
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author | Goldstein, Ilan Ehrenreich, Ian M. |
author_facet | Goldstein, Ilan Ehrenreich, Ian M. |
author_sort | Goldstein, Ilan |
collection | PubMed |
description | Spontaneous and induced mutations frequently show different phenotypic effects across genetically distinct individuals. It is generally appreciated that these background effects mainly result from genetic interactions between the mutations and segregating loci. However, the architectures and molecular bases of these genetic interactions are not well understood. Recent work in a number of model organisms has tried to advance knowledge of background effects both by using large‐scale screens to find mutations that exhibit this phenomenon and by identifying the specific loci that are involved. Here, we review this body of research, emphasizing in particular the insights it provides into both the prevalence of background effects across different mutations and the mechanisms that cause these background effects. |
format | Online Article Text |
id | pubmed-7984271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79842712021-03-24 The complex role of genetic background in shaping the effects of spontaneous and induced mutations Goldstein, Ilan Ehrenreich, Ian M. Yeast Yeast Extract Spontaneous and induced mutations frequently show different phenotypic effects across genetically distinct individuals. It is generally appreciated that these background effects mainly result from genetic interactions between the mutations and segregating loci. However, the architectures and molecular bases of these genetic interactions are not well understood. Recent work in a number of model organisms has tried to advance knowledge of background effects both by using large‐scale screens to find mutations that exhibit this phenomenon and by identifying the specific loci that are involved. Here, we review this body of research, emphasizing in particular the insights it provides into both the prevalence of background effects across different mutations and the mechanisms that cause these background effects. John Wiley and Sons Inc. 2020-12-14 2021-03 /pmc/articles/PMC7984271/ /pubmed/33125810 http://dx.doi.org/10.1002/yea.3530 Text en © 2020 The Authors. Yeast published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Yeast Extract Goldstein, Ilan Ehrenreich, Ian M. The complex role of genetic background in shaping the effects of spontaneous and induced mutations |
title | The complex role of genetic background in shaping the effects of spontaneous and induced mutations |
title_full | The complex role of genetic background in shaping the effects of spontaneous and induced mutations |
title_fullStr | The complex role of genetic background in shaping the effects of spontaneous and induced mutations |
title_full_unstemmed | The complex role of genetic background in shaping the effects of spontaneous and induced mutations |
title_short | The complex role of genetic background in shaping the effects of spontaneous and induced mutations |
title_sort | complex role of genetic background in shaping the effects of spontaneous and induced mutations |
topic | Yeast Extract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984271/ https://www.ncbi.nlm.nih.gov/pubmed/33125810 http://dx.doi.org/10.1002/yea.3530 |
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